Adjusting medicament delivery parameters in an open loop medicament delivery mode
Inventors
Lee, Joon Bok • O'Connor, Jason • Zheng, Yibin • Hardy, Jonathan
Assignees
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Publication Number
US-12564679-B2
Publication Date
2026-03-03
Expiration Date
Abstract
The exemplary embodiments provide an automated approach for adjusting the medicament delivery rate to the user when operating in an open loop manner (“open mode”). The approach relies upon an insulin delivery history to the user make adjustments to the medicament delivery rate in the open mode. In particular, the exemplary embodiments may look at the medicament delivery history while the medicament delivery device is operating in a closed loop manner (“closed mode”) to determine how to adjust the open mode medicament delivery rate. It is presumed that in closed mode, the control system of the medicament device has gained knowledge over time about how to control the medicament delivery rate to produce good treatment outcomes for the user. The exemplary embodiments leverage this knowledge to adjust the open mode medicament delivery rates. Medicament bolus deliveries in open mode may also be adjusted in like fashion.
Core Innovation
The invention provides systems and non-transitory storage medium instructions for a medicament delivery device that operates in an open loop mode and a closed loop mode. The processor determines a first average of a total basal delivery amount of medicament that is delivered in the closed loop mode during a same segment of time in a period, and compares the first average with an amount of medicament that is to be delivered in the open loop mode for the segment of time to determine a difference.
Based on the comparing, the processor displays a change in the amount of medicament that is programmed to be delivered in the open loop mode for the segment of time to reduce the difference and/or programmatically causes the amount of medicament that is programmed to be delivered for the segment of time in the open loop mode to be adjusted to reduce the difference. The adjustment can be performed using a second average, including a weighted combination of the programmed medicament amount and the second average, and the magnitude of the adjustment can depend on predefined difference ranges mapped to discrete change amounts.
The invention includes adjusting insulin-based parameters based on the determined difference between closed-loop delivered basal amounts and programmed open-loop amounts. The processor adjusts at least one of an insulin to carbohydrate ratio (ICR) of the user or a correction factor of the user based on the determined difference, and then uses the adjusted ICR and/or the adjusted correction factor in determining a recommended bolus dosage of medicament.
Claims Coverage
The independent claims are clm-00001, clm-00008, and clm-00015, each covering open-loop and closed-loop medicament delivery with comparison-based adjustment. Across the independent claims, there are four inventive features: computing closed-loop basal averages for the same segment of time, comparing those averages to programmed open-loop amounts to determine a difference, using that difference to display and/or programmatically adjust open-loop programming, and adjusting ICR and/or correction factor to determine a recommended bolus dosage.
Closed-loop basal average comparison for an open-loop segment
Determine a first average over a period of a total basal delivery amount of medicament that is delivered in the closed loop mode during a same segment of time, and compare the first average with an amount of medicament that is to be delivered in the open loop mode for the segment of time to determine a difference.
Display and/or programmatic adjustment of open-loop programmed amount to reduce difference
Based on the comparing, display a change in the amount of medicament that is programmed to be delivered for the segment of time in the open loop mode to reduce the difference, and/or programmatically cause the amount of medicament that is programmed to be delivered for the segment of time in the open loop mode to be adjusted to reduce the difference.
Suggestion and/or programmatic adjustment in an electronic device
Determine a first average over a period of a total basal delivery amount of medicament that is delivered in the closed loop mode during a same segment of time for intervals in the period; compare the first average with an amount of medicament that is programmed to be delivered for the segment of time in the open loop mode to determine a difference; and based on the comparing, display a suggestion of a change in the amount of medicament that is programmed to be delivered for the segment of time in the open loop mode to reduce the difference, and/or programmatically cause the amount of medicament that is programmed to be delivered for the segment of time in the open loop mode to be adjusted to reduce the difference.
Adjust insulin-to-carbohydrate ratio and/or correction factor from closed-loop versus open-loop basal difference
Determine a difference by comparing the average over the period of intervals of the total basal delivery amount of the medicament delivered in the closed loop mode during the segment of time with an amount of medicament that is programmed to be delivered in the open loop mode for the segment of time; based on the determined difference, adjust at least one of an insulin to carbohydrate ratio (ICR) of the user or a correction factor of the user; and use the adjusted ICR or the adjusted correction factor in determining a recommended bolus dosage of medicament for the user.
Across the independent claims, the inventive coverage focuses on using closed-loop basal delivery history averaged over a period or intervals to form a difference relative to programmed open-loop basal amounts for a same segment of time, and then using that difference to drive a display of a change or suggestion and/or programmatic adjustment of open-loop programming. One independent claim further covers adjusting ICR and/or correction factor to determine a recommended bolus dosage.
Stated Advantages
Reduce the difference between closed loop delivered basal amount and open loop programmed amount.
Reduce the difference by displaying a change and/or programmatically adjusting the programmed open loop amount.
Determine a recommended bolus dosage using adjusted ICR and/or adjusted correction factor.
Display the magnitude of an adjustment when the adjustment is performed.
Documented Applications
A medicament delivery device operating in open loop mode and closed loop mode, including insulin-based systems, that uses closed-loop delivery history to suggest and/or programmatically adjust open-loop basal programming for a segment of time.
A management device or electronic device implementation that displays suggested changes and/or programmatically adjusts programmed medicament delivery amounts during open-loop segments based on comparing closed-loop basal averages to open-loop programmed amounts.
Adjustment of insulin to carbohydrate ratio (ICR) and/or correction factor based on closed-loop versus open-loop basal delivered differences to determine a recommended bolus dosage.
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