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Assignees
Member
FreMon ScientificFreMon Scientific develops biomedical platforms focused on dry, electronically controlled thawing of blood, plasma, and cell therapy products. Its core solutions include portable thawing devices and disposable thermal sleeves for optimized, contamination-reduced, and traceable thawing workflows. The systems are validated for regulatory compliance, supported by clinical studies, and utilized in hospitals, laboratories, and production settings globally.
FreMon Scientific develops biomedical platforms focused on dry, electronically controlled thawing of blood, plasma, and cell therapy products. Its core solutions include portable thawing devices and disposable thermal sleeves for optimized, contamination-reduced, and traceable thawing workflows. The systems are validated for regulatory compliance, supported by clinical studies, and utilized in hospitals, laboratories, and production settings globally.
Publication Number
US-12563643-B2
Publication Date
2026-02-24
Expiration Date
Abstract
A device for dry thawing biological substances and methods for using the same are provided. The dry thawing device can be configured to receive a biological substance within a woven pocket. The woven pocket can include temperature sensors configured to measure a temperature of the interior volume and heating elements configured to heat an interior of the woven pocket 106 based upon the measured temperature to avoid overheating or underheating the biological substance during thawing. The woven pocket can also include mechanical vibrators configured to agitate the biological substance during thawing to achieve an approximately homogeneous temperature profile within the woven pocket.
Core Innovation
The invention relates to a dry thawing device for dry thawing a biological substance. The device includes a frame comprising an aperture and a lip extending outward from the aperture, where the lip comprises an electrical interface. A flexible woven pocket having a woven distal end and an inner volume is dimensioned to receive a container containing a biological substance and the flexible woven pocket comprises one or more electrically conductive fibers and one or more electrically insulating fibers interwoven together to form a woven side that flexes according to a contour of the container.
The woven pocket is directly coupled to the frame and positioned within the aperture. The flexible woven pocket further comprises a temperature sensor disposed to be in the woven side in between the fibers of the woven side and configured to move along with the flexing woven side when the woven side flexes and to contact the container to thermally communicate with the biological substance received within the woven pocket. The device also includes a heating element configured to supply heat to the inner volume of the woven pocket based upon a temperature measurement acquired by the temperature sensor.
To facilitate homogenous thawing within the container, the device further includes a mechanical vibrator configured to vibrate the flexible woven pocket and the biological substance contained in the container. In this way, heat delivery is based on temperature measurement acquired by the temperature sensor, while vibration facilitates homogenous thawing within the container.
Claims Coverage
Independent claim clm-00001 contains the core dry-thawing structure and functional cooperation, including six main inventive features.
Frame with aperture and outward lip electrical interface
The device includes a frame comprising an aperture and a lip extending outward from the aperture, wherein the lip comprises an electrical interface.
Flexible woven pocket with interwoven conductive and insulating fibers
The device includes a flexible woven pocket having a woven distal end and an inner volume dimensioned to receive a container containing a biological substance, where the flexible woven pocket comprises one or more electrically conductive fibers and one or more electrically insulating fibers interwoven together to form a woven side that flexes according to a contour of the container.
Direct coupling of the woven pocket within the aperture
The woven pocket is directly coupled to the frame and positioned within the aperture.
Movable temperature sensor disposed in the woven side contacting the container
The woven pocket further comprises a temperature sensor disposed to be in the woven side in between the fibers of the woven side and configured to move along with the flexing woven side when the woven side flexes and to contact the container to thermally communicate with the biological substance received within the woven pocket.
Heating element supplying heat based on sensor-acquired temperature measurement
A heating element configured to supply heat to the inner volume of the woven pocket based upon a temperature measurement acquired by the temperature sensor.
Mechanical vibrator for homogeneous thawing
A mechanical vibrator configured to vibrate the flexible woven pocket and the biological substance contained in the container to facilitate homogenous thawing within the container.
The independent claim coverage centers on a dry thawing device that couples a flexing, conductive/insulating fiber woven pocket to a frame with an electrical interface, uses a movable temperature sensor contacting the container to thermally communicate with the biological substance, drives a heating element based on the acquired temperature measurement, and uses mechanical vibration to facilitate homogenous thawing.
Stated Advantages
Reduced microbial contamination.
More uniform thawing quality.
Lower maintenance than water-bath approaches.
Documented Applications
Dry thawing of a biological substance contained in a container using a dry thawing device with a flexible woven pocket, sensor-based heating, and mechanical vibration to facilitate homogenous thawing.
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