Method for preparing a haemostatic composition
Inventors
Hammershøj, Peter Lund • Larsen, Kristian • Johns, Douglas B. • Smith, Nicole • Cardinale, Michael • Ferrara, Gabriella • Zhang, Guanghui
Assignees
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Publication Number
US-12544483-B2
Publication Date
2026-02-10
Expiration Date
Abstract
The present disclosure relates to a method for preparing a haemostatic composition comprising thrombin, the method comprising the step of reconstituting a dry thrombin directly in a paste, such as a paste comprising a biocompatible polymer. The haemostatic composition comprising thrombin may be prepared from a dry thrombin composition and a paste in a single step operation and be used for treatment of a wound.
Core Innovation
The disclosed invention relates to a method of preparing a haemostatic composition having a substantially homogenous distribution of thrombin. The method includes providing a dry thrombin composition in a first syringe and providing a paste comprising a biocompatible polymer in a second syringe, wherein the paste comprises the biocompatible polymer in a content of 7% w/w to 20% w/w.
The syringes are connected using a suitable connector, and the contents of the syringes are transferred back and forth between the connected syringes to achieve a substantially homogenous distribution of thrombin in the haemostatic composition. The patent content describes this approach as reconstituting dry thrombin directly inside a biocompatible polymer paste using interconnection of containers followed by transfers back and forth.
The disclosed approach is also implemented as a kit for preparing a haemostatic paste with a substantially homogenous distribution of thrombin. The kit includes a first syringe comprising a dry thrombin composition and a second syringe comprising a paste comprising a biocompatible polymer in a content of 7% w/w to 20% w/w, and the two syringes are interconnectable to allow for transferring the contents between the syringes.
Claims Coverage
The partial content identifies two independent claims: a method for preparing a haemostatic composition with substantially homogenous thrombin distribution, and a kit for preparing a haemostatic paste with the same distribution. Across these independent claims, the inventive features center on combining dry thrombin with a biocompatible polymer paste via interconnectable syringes and back-and-forth transfer to produce a substantially homogeneous thrombin distribution, with the biocompatible polymer content constrained to 7% w/w to 20% w/w.
Interconnectable syringes for back-and-forth transfer mixing
providing a dry thrombin composition in a first syringe; providing a paste comprising a biocompatible polymer in a second syringe; connecting the first syringe and the second syringe using a suitable connector; and transferring the contents of the syringes back and forth between the connected syringes to achieve a substantially homogenous distribution of thrombin in the haemostatic composition.
Biocompatible polymer paste with defined polymer content
a paste comprising the biocompatible polymer in a content of 7% w/w to 20% w/w in the second syringe.
Kit with interconnectable first and second syringes
a first syringe comprising a dry thrombin composition; a second syringe comprising a paste comprising a biocompatible polymer, wherein the paste comprises the biocompatible polymer in a content of 7% w/w to 20% w/w; and the two syringes are interconnectable to allow for transferring the contents between the syringes.
Overall, the claim coverage centers on using interconnectable syringes with a suitable connector and back-and-forth transfers to produce a substantially homogenous distribution of thrombin in a haemostatic composition, and on providing that arrangement as a kit with a defined biocompatible polymer paste content of 7% w/w to 20% w/w.
Stated Advantages
Documented Applications
No documented applications found
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