Method for producing active agent administering systems by means of pad printing processes
Inventors
Hille, Thomas • Botzem, Petra • Wionzek, Albert
Assignees
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Publication Number
US-12508257-B2
Publication Date
2025-12-30
Expiration Date
Abstract
The present invention relates to a pad printing method for producing an administration form for a pharmaceutical active agent, wherein the method comprises providing a substrate of the administration form and transferring the active agent by means of a pad from a cliché onto the substrate, wherein the area of the cliché is larger than the active-agent-containing area printed onto the substrate. This method is especially suitable for producing transdermal therapeutic systems with volatile active agents. The present invention also relates to arrangements by means of which a method of this kind can be implemented.
Core Innovation
The invention is a pad printing method for producing an administration form for a pharmaceutical active agent. The method provides a non-absorbent substrate of the administration form and transfers the active agent by means of a pad from a cliche9 onto the non-absorbent substrate. The area of the indentation of the cliche9 is larger than the area of the active-agent-containing imprint printed onto the non-absorbent substrate.
The administration form is adapted to a transdermal therapeutic system (TTS), and the pharmaceutical active agent is a volatile active agent with a boiling point no greater than 250b0C at 101.3 kPa. The document highlights nicotine and linalool, and also mentions essential oils and esters of essential oils, emphasizing suitability for volatile and oxidation-sensitive actives.
An additional aspect is an arrangement for applying the active agent to a non-absorbent substrate with a pad printing system. The arrangement includes a device with a pad and a cliche9, with the cliche9 filled at least in part with an active-agent-containing formulation, and the non-absorbent substrate receiving the formulation from the pad. The device is adapted so that the contact area of the pad is smaller than the area of an indentation of the cliche9.
Claims Coverage
The document includes two independent claims covering the pad printing method and a device arrangement for applying the active agent. Across the independent claims, the main inventive features are the relative area relationship between the cliche9 indentation and the printed imprint or pad contact area, together with a non-absorbent substrate and formulation delivery via pad printing.
Larger cliche9 indentation area than imprint area on a non-absorbent substrate
A pad printing method providing a non-absorbent substrate and transferring the active agent by means of a pad from a cliche9 onto the non-absorbent substrate, wherein the area of the indentation of the cliche9 is larger than the area of the active-agent-containing imprint printed onto the non-absorbent substrate.
Pad contact area smaller than cliche9 indentation area
An arrangement for applying an active agent to a non-absorbent substrate with the aid of a pad printing system, comprising a device with a pad and a cliche9, wherein the cliche9 is filled at least in part with an active-agent-containing formulation, and a non-absorbent substrate for receiving the active-agent-containing formulation from the pad from the device, wherein the device is adapted such that the contact area of the pad is smaller than the area of an indentation of the cliche9.
Overall, the claim coverage centers on the relative area relationship between the cliche9 indentation and the pad interaction or printed imprint on a non-absorbent substrate, implemented through pad printing using a cliche9 filled with an active-agent-containing formulation. Further refinements are directed to administration as a TTS and to volatile actives defined by a boiling-point threshold.
Stated Advantages
Enables reliable printed transfer of the active agent by preventing insufficient transfer.
Reduces active-agent waste grid effects compared with prior TTS approaches.
Supports suitability for volatile and oxidation-sensitive actives by using a formulation characterized by a boiling point no greater than 250b0C at 101.3 kPa.
Documented Applications
Production of an administration form for a pharmaceutical active agent using pad printing on a non-absorbent substrate.
Production of a transdermal therapeutic system (TTS) by pad printing the active agent onto a non-absorbent substrate.
Application of an active agent to a non-absorbent substrate using an arrangement comprising a pad printing system with a pad and a cliche9.
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