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Publication Number
US-12507691-B2
Publication Date
2025-12-30
Expiration Date
Abstract
A system for lung preservation is described. The system includes a cooler at least partially housing a cooling coil, the cooling coil including a proximal end configured to connect to an oxygen source and a distal end configured to connect to endotracheal tubing. The endotracheal tubing is in fluid communication with a conduit extending through the cooling coil. A positive end expiratory pressure valve connected to the endotracheal tubing. A method for preserving a lung and a method for preserving a lung for transportation are also described.
Core Innovation
The invention provides an oxygen-cooling lung preservation system that uses a cooler housing a cooling coil to deliver cooled oxygen to endotracheal tubing and, thereby, to airways within a lung. The cooling coil has a proximal end configured to connect to an oxygen source and a distal end configured to connect to endotracheal tubing, with the endotracheal tubing in fluid communication with a conduit extending through the cooling coil.
The system further includes a positive end expiratory pressure valve connected to the endotracheal tubing and a temperature sensor connected to at least one of the cooling coil and the endotracheal tubing. A controller is connected to the temperature sensor and a display is connected to the controller, and the controller is configured to send an alert signal to the display if the temperature reading falls outside the range between 0 degrees Celsius and 4 degrees Celsius.
The invention supplies a continuous flow of cooled oxygen to the lung airways via the cooling coil while maintaining a positive end expiratory pressure. The cooled oxygen is maintained at a temperature between 0 degrees Celsius and 4 degrees Celsius, and the invention encompasses transporting a housing while supplying the continuous flow of cooled oxygen to the lung airways with the cooled oxygen maintained within the same temperature range.
Claims Coverage
Independent claims cover three inventive scopes: a lung preservation system with a cooled-oxygen delivery path and temperature alerting at 084b0C, a preservation method supplying continuous cooled oxygen with PEEP at 084b0C, and a transportation method preserving an ex vivo lung during transport under the same continuous cooled-oxygen/PEEP and 084b0C constraint. Across these, the core inventive features are tied to the cooling coil within a cooler housing, continuous cooled oxygen to airways, positive end expiratory pressure, and the maintained temperature range of 0b0C to 4b0C, with claim 1 additionally requiring a temperature sensor, controller, display, and an alert signal outside 0b0C to 4b0C.
Cooler housing a cooling coil connecting an oxygen source to endotracheal tubing
A system for lung preservation comprising a cooler at least partially housing a cooling coil, the cooling coil comprising a proximal end configured to connect to an oxygen source and a distal end configured to connect to endotracheal tubing; the endotracheal tubing in fluid communication with a conduit extending through the cooling coil.
Positive end expiratory pressure with temperature sensing and alerting
A positive end expiratory pressure valve connected to the endotracheal tubing; a temperature sensor connected to at least one of the cooling coil and the endotracheal tubing; a controller connected to the temperature sensor; and a display connected to the controller, wherein the controller is configured to send an alert signal to the display if the temperature reading falls outside of the range between 0 degrees Celsius and 4 degrees Celsius.
Placing a lung in a cooler housing and supplying continuous cooled oxygen while maintaining PEEP at 084b0C
A method for preserving a lung comprising placing a lung within a cooler housing comprising a cooling coil at least partially disposed within the housing; and supplying a continuous flow of cooled oxygen to airways within the lung via the cooling coil while maintaining a positive end expiratory pressure, wherein the cooled oxygen is maintained at a temperature between 0 degrees Celsius and 4 degrees Celsius.
Transporting a lung during continuous cooled-oxygen delivery with PEEP at 084b0C
A method for preserving a lung for transportation comprising placing a lung within a cooler housing; supplying a continuous flow of cooled oxygen to airways within the lung while maintaining a positive end expiratory pressure; and transporting the housing while supplying the continuous flow of cooled oxygen to airways within the lung, wherein the cooled oxygen is maintained at a temperature between 0 degrees Celsius and 4 degrees Celsius.
Overall, the claims require a cooler housing with a cooling coil delivering continuous cooled oxygen to lung airways via endotracheal tubing, with positive end expiratory pressure maintained and the cooled oxygen maintained at 0 degrees Celsius to 4 degrees Celsius. The system claim further adds temperature sensing with controller/display alerting when readings fall outside 0 degrees Celsius to 4 degrees Celsius.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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