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Assignees
Member
FreMon ScientificFreMon Scientific develops biomedical platforms focused on dry, electronically controlled thawing of blood, plasma, and cell therapy products. Its core solutions include portable thawing devices and disposable thermal sleeves for optimized, contamination-reduced, and traceable thawing workflows. The systems are validated for regulatory compliance, supported by clinical studies, and utilized in hospitals, laboratories, and production settings globally.
FreMon Scientific develops biomedical platforms focused on dry, electronically controlled thawing of blood, plasma, and cell therapy products. Its core solutions include portable thawing devices and disposable thermal sleeves for optimized, contamination-reduced, and traceable thawing workflows. The systems are validated for regulatory compliance, supported by clinical studies, and utilized in hospitals, laboratories, and production settings globally.
Publication Number
US-12504355-B2
Publication Date
2025-12-23
Expiration Date
Abstract
Dry thawing systems and devices for thawing biological substances are provided herein. Methods for thawing biological substances are also provided.
Core Innovation
The invention relates to an overwrap bag to contain a biological substance container and to be placed in a thawing system comprising a housing and a chamber frame configured to receive the biological substance container contained in the overwrap bag. The overwrap bag includes a flexible or semi-rigid cavity sized to be received in the chamber frame, with a pre-formed funnel-shaped portion configured to receive and align the biological substance container. The cavity funnels the biological substance container toward a bottom portion so that the container is aligned for controlled temperature measurement.
The pre-formed funnel-shaped portion comprises a top portion, a substantially straight stem portion, and a bottom portion, with widths configured so that a biological substance container passing the top portion is funneled toward the bottom portion and aligned by the substantially straight stem portion. A temperature sensor is coupled to a portion of the flexible or semi-rigid cavity and positioned between the top portion and the bottom portion within a second width corresponding to the funnel geometry. The substantially straight stem portion aligns the biological substance container to contact the portion of the cavity where the temperature sensor is coupled, enabling measurement of the temperature of the biological substance container containing the biological substance.
The overwrap bag further comprises an identifier for the biological substance and comprises a cover attached to one end of the flexible or semi-rigid cavity, including a portion to mount the overwrap bag to the chamber frame. The pre-formed funnel-shaped cavity is shaped to funnel the biological substance container toward the bottom portion while the substantially straight stem portion aligns the container relative to the temperature sensor. The identifier can include RFID, and the temperature sensor is integrated and thermally arranged with respect to the overwrap bag structure.
Claims Coverage
The document provided includes one independent claim for an overwrap bag for use in a thawing system. The inventive features focus on the overwrap bag cavity geometry for funneling and alignment, placement and coupling of a temperature sensor for measuring the biological substance container temperature, and inclusion of an identifier for the biological substance, with a cover for mounting to a chamber frame.
Funnel-shaped overwrap cavity to align the biological substance container
The overwrap bag comprises a flexible or semi-rigid cavity sized to be received in the chamber frame, wherein the cavity includes a pre-formed funnel-shaped portion configured to receive and align the biological substance container; the funnel-shaped cavity is shaped to funnel the biological substance container toward the bottom portion, and the substantially straight stem portion aligns the biological substance container with respect to the second width so the container is aligned by the substantially straight stem portion.
Temperature sensor coupled within the funnel geometry for measuring container temperature
A temperature sensor is coupled to a portion of the flexible or semi-rigid cavity and positioned in between the top portion and the bottom portion and within the second width with respect to the pre-formed funnel-shaped portion, configured to measure a temperature of the biological substance container containing the biological substance, wherein the substantially straight stem portion is configured to align the biological substance with respect to the temperature sensor so the biological substance container contacts the portion of the cavity where the temperature sensor is coupled.
Identifier for the biological substance
The overwrap bag comprises an identifier for the biological substance, including RFID.
Cover attached to mount the overwrap bag to the chamber frame
The overwrap bag further comprises a cover attached to one end of the flexible or semi-rigid cavity and comprises a portion to mount the overwrap bag to the chamber frame.
Across the provided independent claim, the overwrap bag defines a pre-formed funnel-shaped cavity with a substantially straight stem portion to funnel and align a biological substance container relative to a coupled temperature sensor, while also including an identifier for the biological substance and a cover that mounts the overwrap bag to the chamber frame.
Stated Advantages
Documented Applications
No documented applications found
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