Compositions and methods for repairing cartilage defects
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Publication Number
US-12496317-B2
Publication Date
2025-12-16
Expiration Date
Abstract
The present disclosure provides compositions and methods for repairing cartilage defects.
Core Innovation
The invention describes treating a chondral and/or osteochondral defect in a human subject by implanting cultured allogeneic chondrocytes grown from a cryogenically frozen cell bank sample on a resorbable collagen membrane. The cells are seeded on the membrane at a specified density [procedural detail omitted for safety]. The description contrasts this approach with autologous matrix-induced chondrocyte implantation, which requires two procedures.
In a rabbit preclinical study, allogeneic and autologous implants produce hyaline-like cartilage, with glycosaminoglycan and type II collagen staining and partial integration at the reported follow-up. The allogeneic group shows no evident inflammatory or immune response. The document also depicts gross repair and comparative histology for control, membrane-only, autologous, and allogeneic groups.
Claims Coverage
The claims define one independent claim directed to treating a chondral and/or osteochondral defect, comprising two inventive features.
Treatment of chondral and/or osteochondral defects
The claim covers implanting a composition into a human subject to treat a chondral and/or osteochondral defect.
Composition comprising allogeneic chondrocytes and a collagen membrane
The composition comprises cultured allogeneic cells including chondrocytes grown from a cryogenically frozen cell bank sample, together with a resorbable collagen membrane. The cells are seeded on the membrane at a specified density [procedural detail omitted for safety].
The independent claim combines a specified allogeneic cell source with a resorbable collagen membrane in an implantation method for chondral and/or osteochondral defects.
Stated Advantages
The description emphasizes treatment with a single invasive procedure, in contrast to the two procedures required for autologous matrix-induced chondrocyte implantation.
Documented Applications
Implantation in a human subject for treatment of a chondral and/or osteochondral defect.
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