Container for biological materials having multiple sealed portions
Inventors
RAMSEY, Tara C. • Rajput, Uzair
Assignees
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Publication Number
US-12495794-B2
Publication Date
2025-12-16
Expiration Date
Abstract
An apparatus is disclosed having a first layer coupled to a second layer via a plurality of seals to define a storage volume that is separable by at least one intermediate seal into a first volume and a second volume. The intermediate seal is applicable after a material is introduced into the storage volume storage. The apparatus includes a first opening into the storage volume and a second opening into the storage volume. The first opening and the second opening are positioned near opposite edges. The apparatus also includes a first frangible region positioned along the intermediate seal and configured for separation of the first volume and the second volume.
Core Innovation
A flexible multi-seal biological-material storage container defines a storage volume between a first layer and a second layer. The flexible container includes first and second end portions and first and second edges, with a plurality of seals coupling the first layer and second layer along at least one of the end portions and edges to form a hermetically sealed storage volume for a target material.
A port is coupled to a first end portion and defines an opening into the storage volume for conveying the target material into the storage volume. After the target material is within the storage volume, an end portion seal is applied at the first end portion to fluidically isolate the port from the storage volume.
An end portion frangible region extends between the first edge and the second edge along the end portion seal and is configured to physically separate the port from the storage volume while keeping the storage volume isolated. The frangible region includes perforations, tear notches, or stress concentration risers, and the container includes provisions for quality control sample removal and verification, including tissue, cells, blood, and biologic preparations.
Claims Coverage
The partial set includes two independent claims, covering both a flexible sealed container system and a method for storing a target material using the same container concepts. Across the independent claims, the inventive coverage centers on four inventive features: a layered flexible container with seals defining a storage volume, conveying a target material via a port, applying an end portion seal to fluidically isolate the port, and using an end portion frangible region to physically separate the port while maintaining isolation.
Layered flexible container defining a storage volume
A flexible container with a first layer and a second layer coupled together, wherein a plurality of seals couple the first layer and second layer along at least the first end portion, the second end portion, the first edge, or the second edge to define a storage volume between the first layer and the second layer.
Port conveying followed by end portion sealing to isolate the port
A port coupled to the first end portion of the flexible container, the port defining an opening into the storage volume through which a target material can be conveyed, and an end portion seal configured to be applied after the target material is within the storage volume, the end portion seal fluidically isolating the port from the storage volume.
End portion frangible region for separation while keeping storage isolated
An end portion frangible region extending between the first edge and the second edge along the end portion seal, the end portion frangible region configured for physically separating the port from the storage volume while keeping the storage volume isolated.
End portion frangible region separation in a storing method maintaining fluidic isolation
A method for storing a target material comprising conveying the target material into a storage volume of a flexible container via a port; sealing an end portion seal following conveyance to fluidically isolate the port from the storage volume; physically separating the port via an end portion frangible region following the sealing of the end portion seal; and maintaining the fluidic isolation of the storage volume via the sealed end portion seal following the physical separation.
The independent claim coverage is anchored in a layered flexible container system where a port is used to convey a target material into a sealed storage volume, the port is then fluidically isolated by sealing an end portion, and the port is physically separated using an end portion frangible region that remains compatible with maintaining isolation of the storage volume.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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