Systems and methods for treating and estimating progression of chronic kidney disease

Inventors

Blanchard, Thomas C. • Usvyat, Len • Wang, Yuedong • Kotanko, Peter • Maddux, Dugan W. • Maddux, Franklin W.

Assignees

Fresenius Medical Care Holdings Inc

Abstract

Exemplary systems and methods for estimating progression of chronic kidney disease in a patient and applying clinical interventions may include determining historic values of at least one patient parameter that varies as a function of the progression of the chronic kidney disease over time, and computationally estimating a trend corresponding to the historic values. Based on the trend, at least one marker may be automatically provided that identifies a clinical intervention and a time in the future when the clinical intervention is expected to be needed. Based on the at least one marker, clinical preparations may be executed at a time prior to the administration of the intervention in order to improve at least one of a) timeliness of the execution of the intervention and b) effectiveness of the intervention.

Core Innovation

The invention provides processor-executable instructions for treating progression of chronic kidney disease (CKD) in a patient by using historic estimated glomerular filtration rate (eGFR) values that vary as a function of the progression of CKD over time. The processor accesses historic eGFR values, determines a trend of future progression based on the historic eGFR values, and calculates predicted future eGFR values based on the trend.

The system generates a visual chart configured for presentation on a computing device display. The visual chart includes the historic eGFR values, a trend line corresponding to the trend, and future eGFR values arranged along the trend line, and automatically provides at least one marker on the trend line that identifies at least one clinical intervention and a time in the future when the clinical intervention is expected to be needed.

Using the marker, the system administers at least one clinical intervention to the patient, and in some embodiments transmits an alert to a device communicatively coupled to the computing device. In embodiments, the marker is determined based on chart information and on accessing a database comprising intervention information indicating eGFR values and associated clinical interventions.

The workflow is updated when additional eGFR values are obtained, including calculating updated historical eGFR values and updating the chart with an updated trend line. In embodiments, the system calculates actual eGFR values, compares the actual values to predicted future values, and adjusts treatment options based on deviation between the actual and predicted values.

Claims Coverage

The partial content includes three independent claims (clm-00001, clm-00010, clm-00016). The inventive coverage is centered on trend-based prediction of future eGFR from historic eGFR values, chart generation with trend lines and future eGFR values, automatic placement of intervention markers on the trend line, and administering interventions or transmitting alerts based on the markers.

The independent claims collectively cover trend-based prediction of future eGFR from historic eGFR values, visualization of historic and predicted eGFR along a trend line, automatic placement of markers that identify a clinical intervention and a future time it is expected to be needed, and then either administering the intervention to the patient or transmitting an alert indicating an upcoming necessary intervention date. Some embodiments further use a database of intervention information to determine the marker and update predictions based on subsequently obtained eGFR values.

Stated Advantages

Documented Applications