Plant antimicrobial compositions and methods of use thereof
Inventors
Mandadi, Kranthi • RAMASAMY, Manikandan • Niraula, Prakash • Irigoyen, Sonia
Assignees
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Publication Number
US-12458025-B2
Publication Date
2025-11-04
Expiration Date
Abstract
Applicants have developed novel methods and compositions for treating, preventing or ameliorating the effects plant phytopathogen infestation in plants, including of Candidatus Liberibacter spp. the causal agents of citrus greening and potato zebrachip disease. Novel compositions include one or more active agents of aminocaproic acid, carbinoxamine maleate, chloroxylenol, chlorpropamide, cinoxacin, duartin, and cyclopentolate hydrochloride as well as their derivatives, or salt/acid forms thereof. Methods of preventing disease development and infestation by plant pathogens are disclosed as well as methods of making, using and producing such compositions.
Core Innovation
The invention relates to plant antimicrobial compositions and methods for treating or preventing growth of bacterial pathogens by administering to a plant, plant part, or the area surrounding the same a composition comprising at least one active effective against bacterial pathogens, together with an environmentally acceptable carrier. The disclosed active ingredients include carbinoxamine maleate, chloroxylenol, chlorpropamide, cinoxacin, duartin, and cyclopentolate hydrochloride, including their salt or acid forms.
The disclosed methods include foliar application, trunk injection, laser ablation, and/or spraying, combined with an environmentally acceptable carrier. The composition is administered to reduce bacterial infections and inhibit bacterial growth, including reduction in bacterial titers as compared with untreated plants, plant parts, or the surrounding area.
The document addresses bacterial pathogen growth in plants in the presence of phytopathogens such as Candidatus Liberibacter associated with citrus greening (HLB) and potato zebra chip (ZC), and extends the pathogen scope to Xylella fastidiosa, Spiroplasma, Clavibacter michiganensis, Pseudomonas syringae, Agrobacterium tumefaciens, and Candidatus Phytoplasma. It also characterizes the problem as unpredictability in identifying effective actives and reports screening results in which hundreds of compounds are screened and only a limited number identified as hits.
Claims Coverage
The document provides two independent claims directed to treating or preventing bacterial pathogen growth in plants and treating soil to reduce hemipteran delivered bacterial infections. Each independent claim defines an inventive core around specific active ingredients, including salt or acid forms, formulated with an environmentally acceptable carrier.
Plant treatment composition for bacterial pathogen growth inhibition
A method of treating or preventing growth of bacterial pathogens comprising administering to a plant, plant part, or the area surrounding the same a composition including at least one active effective at treating or preventing growth of said bacterial pathogens selected from carbinoxamine maleate, chloroxylenol, chlorpropamide, cinoxacin, duartin, and cyclopentolate hydrochloride, their salt or acid forms, and an environmentally acceptable carrier, wherein administering is by foliar application, trunk injection, laser ablation, and/or spraying.
Soil treatment to reduce hemipteran delivered bacterial infections
A method of treating soil to reduce hemipteran delivered bacterial infections in plant populations therein comprising administering to said soil a composition including at least one active effective at reducing said hemipteran delivered bacterial infections selected from carbinoxamine maleate, chloroxylenol, chlorpropamide, cinoxacin, duartin, and cyclopentolate hydrochloride, their salt or acid forms, and an environmentally acceptable carrier.
Across the two independent claims, the inventive coverage centers on using specified actives in an environmentally acceptable carrier to inhibit bacterial pathogen growth, with administration options limited to plant-directed modalities for one claim and soil-directed treatment for the other to reduce hemipteran delivered infections.
Stated Advantages
Reduces bacterial titers compared with untreated plants, plant parts, or the surrounding area.
Attenuates symptoms in treated plants, with described dose-dependent symptom attenuation.
Provides a method for treating or preventing growth of bacterial pathogens in plants using environmentally acceptable carrier compositions.
Documented Applications
In planta foliar spraying efficacy is described, including reduction in pathogen titers and symptom attenuation in treated plants.
Soil treatment is described as a method to reduce hemipteran delivered bacterial infections in plant populations.
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