Metal oxide encapsulated drug compositions and methods of preparing the same
Inventors
Neikirk, Colin C. • Frankel, Jonathan
Assignees
Interested in licensing this patent?
MTEC can help explore whether this patent might be available for licensing for your application.
Publication Number
US-12447132-B2
Publication Date
2025-10-21
Expiration Date
Abstract
A method of preparing a pharmaceutical composition having a drug-containing core enclosed by one or more metal oxide materials is provided. The method includes the sequential steps of (a) loading the particles comprising the drug into a reactor, (b) applying a vaporous or gaseous metal precursor to the particles in the reactor, (c) performing one or more pump-purge cycles of the reactor using inert gas, (d) applying a vaporous or gaseous oxidant to the particles in the reactor, and (e) performing one or more pump-purge cycles of the reactor using inert gas. The temperature of the particles does not exceed 35° C. This produces a pharmaceutical composition comprising a drug containing core enclosed by one or more metal oxide materials.
Core Innovation
The invention relates to metal-oxide-encapsulated pharmaceutical compositions in which a drug-containing core is enclosed by a conformal inorganic oxide coating layer. The coating layer comprises an inorganic oxide selected from aluminum oxide, titanium oxide, and zinc oxide and has a thickness of 0.1 nm-100 nm. The antibody-containing core comprises a lyophilized or spray-dried antibody.
The invention also provides a method of preparing such a coated pharmaceutical composition by forming one or more metal oxide materials that enclose an antibody-containing core. Particles comprising an antibody are loaded into a reactor, and a vaporous or gaseous metal precursor is applied to the particles. One or more pump-purge cycles of the reactor are performed using an inert gas, then vaporous or gaseous water is applied as an oxidant, followed by one or more pump-purge cycles using the inert gas.
Steps (b)-(e) are repeated one or more times to increase total thickness of the one or more metal oxide materials. Each inert-gas pump-purge cycle flows inert gas into the reactor chamber to a desired pressure and then pumps the inert gas out until the pressure is below 1 torr, and the temperature of the particles does not exceed 35°C.
Claims Coverage
The document includes two independent claims that cover a coated pharmaceutical composition and a low-temperature method for preparing such coated particles. Across the independent claims, the inventive features are centered on conformal inorganic-oxide encapsulation of an antibody-containing core and a sequential oxidation/coating-build method with controlled temperature and inert-gas purging.
Conformal inorganic oxide encapsulation of lyophilized or spray-dried antibody cores
A composition comprising coated particles comprising an antibody-containing core enclosed by a conformal coating layer, wherein the antibody-containing core comprises a lyophilized or spray-dried antibody, wherein the coating layer comprises an inorganic oxide selected from aluminum oxide, titanium oxide, and zinc oxide, and wherein the coating layer is 0.1 nm-100 nm thick.
Sequential metal-precursor/water oxidant coating build with inert-gas pump-purge under low particle temperature
A method of preparing a pharmaceutical composition of coated particles comprising an antibody-containing core enclosed by one or more metal oxide materials, wherein the antibody-containing core comprises an antibody, the method comprising loading particles comprising an antibody into a reactor, applying a vaporous or gaseous metal precursor, performing one or more pump-purge cycles using an inert gas, applying vaporous or gaseous water as an oxidant, performing one or more pump-purge cycles using the inert gas, and repeating steps (b)-(e) to increase total thickness, wherein each pump-purge cycle comprises flowing inert gas into the reactor to a desired pressure and pumping the inert gas out until the pressure is below 1 torr, and wherein the temperature of the particles does not exceed 35°C.
Overall, the claim coverage ties a conformal aluminum oxide, titanium oxide, or zinc oxide coating layer (0.1 nm-100 nm) around a lyophilized or spray-dried antibody-containing core to a sequential coating-build method using a vapor/gas metal precursor followed by vapor/gas water oxidant, with inert-gas pump-purge cycles constrained by inert-gas pressure below 1 torr and particle temperature not exceeding 35°C.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
Interested in licensing this patent?