Systems and methods for ocular laser surgery and therapeutic treatments
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Publication Number
US-12447048-B2
Publication Date
2025-10-21
Expiration Date
Abstract
Disclosed are systems, devices and methods for laser microporation for rejuvenation of tissue of the eye, for example, regarding aging of connective tissue and rejuvenation of connective tissue by scleral rejuvenation. The systems, devices and methods disclosed herein restore physiological functions of the eye including restoring physiological accommodation or physiological pseudo-accommodation through natural physiological and biomechanical phenomena associated with natural accommodation of the eye. In some embodiments, the laser system may be configured to treat ocular tissue off axis or in a region of the eye which is distinct from the visual axis or directed away from the pupil of the eye where the gaze of the eye is.
Core Innovation
The disclosure provides a system for delivering microporation medical treatments to biological tissue to improve biomechanics of an eye. The system includes a controller and a laser head system having a laser subsystem that generates a beam of laser radiation on a treatment-axis not aligned with a patient's visual-axis, and a lens operable to focus the beam of laser irradiation onto a target tissue.
The system further includes an eye tracking subsystem for tracking landmarks and movements of the eye, and a depth control subsystem for controlling a depth of microporation on the target tissue. The controller is operable to control movements of the laser subsystem, including at least one of a pitch movement, a swivel movement, and a yaw movement, so off-axis treatment is coordinated with eye tracking and depth control.
The disclosure also describes pore-pattern design concepts for the pattern of pores, including lattices and tessellations and spiral/phyllotactic patterns based on named spiral relationships. Example spiral pattern families include Archimedean, Euler, Fermat’s, hyperbolic, lituus, logarithmic, Fibonacci, and golden spirals, or combinations thereof.
Reported outcomes in the disclosure include tissue responses observed over time, including histology showing pores remain patent and reduced inflammation/necrosis over time. The disclosure additionally describes a depth control approach that judges pore depth between pulses and supports control based on measured depth, together with detection of vascular and anatomical features to avoid undesired target regions.
Claims Coverage
The document includes one independent claim directed to a system for delivering off-axis ocular microporation treatments to improve eye biomechanics, with additional refinement in dependent claims that specify scanning, pore-pattern geometry, pore-depth measurement/verification, and related system components. Inventive features explicitly emphasized across the independent claim include an off-axis treatment-axis laser, eye tracking, depth control, and controller-driven laser head motion using pitch/swivel/yaw.
Off-axis subsurface microporation laser treatment axis
A laser subsystem generating a beam of laser radiation on a treatment-axis not aligned with a patient's visual-axis, operable for subsurface ablative medical treatments to create a pattern of pores that improves biomechanics, and a lens operable to focus the beam of laser irradiation onto a target tissue.
Eye tracking subsystem for landmark and eye movement tracking
An eye tracking subsystem for tracking landmarks and movements of the eye.
Depth control subsystem for controlling microporation depth
A depth control subsystem for controlling a depth of microporation on the target tissue.
Controller-driven laser head motion using pitch/swivel/yaw
A controller operable to control the movements of the laser subsystem including at least one of a pitch movement, a swivel movement and a yaw movement.
Spiral pore-pattern selection
The pattern of pores is defined by a spiral pattern chosen from Archimedean, Euler, Fermat’s, hyperbolic, lituus, logarithmic, Fibonacci, and golden spirals, or combinations thereof.
Scanning system for scanning a focus spot over target tissue
A scanning system that scans a focus spot over an area of the target tissue using the eye tracking and depth control subsystems.
Pore depth measured and judged by depth control subsystem
A depth of the pores is measured and judged by the depth control subsystem.
Pore depth proportional to total laser energy
A depth of the pores is proportional to a total laser energy.
Overall, the claim coverage centers on an ocular microporation system that improves biomechanics using an off-axis subsurface ablative laser focused by a lens, while coordinating eye tracking and depth control and using controller-driven laser head motion. Dependent refinements specify spiral selection for pore geometry and add scanning plus depth measurement/judging and a stated proportional relationship between pore depth and total laser energy.
Stated Advantages
Improves biomechanics of an eye by creating a pattern of pores using subsurface ablative microporation medical treatments.
Maintains the pores in a patent state as observed by histology.
Reduces inflammation/necrosis over time as reported in histology.
Documented Applications
Ocular laser microporation for ocular rejuvenation, including “scleral rejuvenation”/“uncrosslinking,” intended to restore physiological accommodation or pseudo-accommodation by creating 3D pore matrices in ocular connective tissue [procedural detail omitted for safety].
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