Continuous processing system and methods for internal and external modifications to nanoparticles
Inventors
Costa, Antonio P. • Burgess, Diane J.
Assignees
Interested in licensing this patent?
MTEC can help explore whether this patent might be available for licensing for your application.
Publication Number
US-12434208-B2
Publication Date
2025-10-07
Expiration Date
Abstract
The present disclosure provides a system for the internal and external modification of nanoparticles in a continuous process. The system includes (a) a first inlet, (b) a second inlet, (c) a first pump in fluid communication with the first inlet, (d) a second pump in fluid communication with the second inlet, (e) a first flow meter positioned between the first pump and the first mixer, (f) a second flow meter positioned between the second pump and the first mixer, and (g) a mixing chamber in fluid communication with the first flow meter and the second flow meter, and (h) a first heat exchanger in fluid communication with the mixing chamber.
Core Innovation
The disclosed technology provides a continuous process system for internal and external modification of pre-formed nanoparticles. The system uses a first inlet and a second inlet, each supplied by a corresponding pump and first and second flow meter, and the flows are combined in a mixing chamber and conditioned by a first heat exchanger to form a plurality of modified pre-formed nanoparticles in a continuous manner.
Downstream measurement is integral to the process. A first analyzer positioned downstream from the first heat exchanger measures a first attribute of the plurality of modified pre-formed nanoparticles, and a second analyzer positioned downstream from the first analyzer measures a second attribute that is different from the first attribute. A controller determines a difference between one or more desired attributes and one or more determined attributes and, in response to the determined difference, adjusts one or more parameters of the system.
The continuous modification framework supports internal and external changes to nanoparticle attributes that can include size and surface charge. The document further describes examples in which controlled mixing and heating and analyzer-determined attributes relate to intra-liposomal crystal growth and molecule encapsulation, as well as post-insertion surface modification, with feedback and diversion concepts that route product based on measured versus desired attributes.
Claims Coverage
The partial content explicitly identifies one independent claim: clm-00001. This independent claim contains the core inventive concept of continuously modifying pre-formed nanoparticles using two inlet feeds, mixing and heating, measuring two different attributes downstream, and using a controller to adjust process parameters based on desired versus determined attribute differences.
Continuous internal and external modification of pre-formed nanoparticles
A system for internal and external modification of pre-formed nanoparticles in a continuous process, including a first inlet and a second inlet, a first pump and a second pump in fluid communication with the respective inlets, a first flow meter and a second flow meter in fluid communication with the respective pumps, a mixing chamber in fluid communication with the first flow meter and the second flow meter, and a first heat exchanger in fluid communication with the mixing chamber.
Two downstream analyzers measuring different attributes
A first analyzer positioned downstream from the first heat exchanger configured to measure a first attribute of a plurality of modified pre-formed nanoparticles, and a second analyzer positioned downstream from the first analyzer configured to measure a second attribute of the plurality of modified pre-formed nanoparticles that is different from the first attribute.
Controller adjusts parameters based on desired versus determined attributes
A controller configured to determine a difference between one or more desired attributes of the plurality of modified nanoparticles and one or more determined attributes of the plurality of modified nanoparticles, and in response to the determined difference adjust one or more parameters of the system.
Overall, the independent claim coverage centers on a continuous two-inlet system that mixes and heat-conditions pre-formed nanoparticles, measures two different downstream attributes via two analyzers, and uses a controller to compare desired versus determined attributes and adjust one or more system parameters accordingly.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
Interested in licensing this patent?