Devices and methods for sample analysis
Inventors
Hayden, Mark A. • Huff, Jeffrey B. • Collier, Nicholas John • YU, Karen Xin Zhou
Assignees
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Publication Number
US-12420279-B2
Publication Date
2025-09-23
Expiration Date
Abstract
Digital microfluidic and analyte detection device includes a first substrate and a second substrate aligned generally parallel to each other with a gap defined therebetween in side view. At least one of the first and second substrates has an electrode array configured to generate electrical actuation forces to urge at least one droplet within the gap along the at least one of the first substrate and the second substrate. The electrode array has a plurality of electrodes defining an electrode array area in plan view. At least one of the first substrate and the second substrate has a well array defining a well array area in plan view. The well array area is bounded within the electrode array area and overlapping a portion of each of the plurality of electrodes. The well array area overlaps less than 75% of the electrode array area in plan view.
Core Innovation
A digital microfluidic and analyte detection device includes a first substrate and a second substrate aligned generally parallel to each other with a gap defined therebetween. At least one of the first substrate and the second substrate has an electrode array configured to generate electrical actuation forces to urge at least one droplet within the gap, and the electrode array has a plurality of electrodes defining an electrode array area in plan view.
The device also includes a well array defining a well array area in plan view on at least one of the first substrate and the second substrate. The well array area is bounded within the electrode array area and overlaps at least a portion of each of the plurality of electrodes, wherein the well array area overlaps less than 75% of the electrode array area in plan view.
An analyte detection module is provided with a substrate having a first layer and a second layer. The first layer includes an electrode array configured to generate electrical actuation forces to urge at least one liquid droplet along a surface of the substrate, and the second layer includes a well array defining a well array area in plan view that is bounded within the electrode array area and overlaps at least a portion of each of the plurality of electrodes, with the well array area overlapping less than 75% of the electrode array area in plan view.
Claims Coverage
The provided set includes two independent claims. The inventive coverage centers on electrode-array actuation of droplets together with a well array whose plan-view area is bounded within the electrode array area and overlaps less than 75% of the electrode array area.
Plan-view bounded electrode and well array overlap under 75%
A digital microfluidic and analyte detection device comprising a first substrate and a second substrate with a gap therebetween; an electrode array configured to generate electrical actuation forces to urge at least one droplet within the gap, the electrode array having a plurality of electrodes defining an electrode array area in plan view; and a well array defining a well array area in plan view that is bounded within the electrode array area and overlaps at least a portion of each of the plurality of electrodes, wherein the well array area overlaps less than 75% of the electrode array area in plan view.
Multi-layer analyte detection module with bounded overlap under 75%
An analyte detection module comprising a substrate having a first layer including an electrode array configured to generate electrical actuation forces to urge at least one liquid droplet along a surface of the substrate, the electrode array having a plurality of electrodes defining an electrode array area in plan view; and a second layer having a well array defining a well array area in plan view, the well array area bounded within the electrode array area and overlapping at least a portion of each of the plurality of electrodes, wherein the well array area overlaps less than 75% of the electrode array area in plan view.
Both independent claims are directed to droplet actuation by an electrode array together with a well array bounded within the electrode array area and overlapping less than 75% of the electrode array area.
Stated Advantages
Documented Applications
No documented applications found
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