Medicament delivery devices for administration of a medicament within a prefilled syringe
Inventors
Edwards, Eric S. • Edwards, Evan T. • Licata, Mark J. • Meyers, Paul F.
Assignees
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Publication Number
US-12420016-B2
Publication Date
2025-09-23
Expiration Date
Abstract
An apparatus includes a housing, a medicament container and a movable member. The medicament container is movable within the housing between a first position and a second position in response to a force produced by an energy storage member. A proximal end portion of the medicament container includes a flange and has a plunger disposed therein. A first shoulder of the movable member exerts the force on the flange to move the medicament container from the first position to the second position. A portion of the first shoulder deforms when the medicament container is in the second position such that at least a portion of the force is exerted upon the plunger. A second shoulder of the movable member exerts a retraction force on the flange to move the medicament container from the second position towards the first position.
Core Innovation
The invention relates to medicament delivery devices that use an energy storage member to move a carrier assembly within a housing in response to actuation. The housing defines a gas chamber that is fluidically isolated from a medicament container interface by seal members in sliding contact and by seal members positioned within recesses.
A medicament container assembly including a container body with an elastomeric member and a needle coupled to a distal end portion is disposed within the housing in a first carrier position, and a portion of the needle is disposed outside of the housing in a second carrier position. The carrier assembly includes a carrier body with a shoulder defining a recess and cooperates with the medicament container assembly to manage force transfer such that injection is initiated after container movement.
For the gas-cylinder implementations, a release member punctures a frangible seal to enable pressurized gas, and a gas relief valve actuated via a gas-valve actuator ends injection by controlling gas flow within the gas chamber. The device can further include a safety lock and a needle sheath system that governs needle exposure, with optional electronic circuit system providing visual and audible instructions.
Claims Coverage
The document includes two independent claims. Across them, the main claim coverage is centered on a gas chamber, a medicament container assembly or prefilled syringe assembly with an elastomeric member and needle, and a carrier assembly driven between a first and second carrier position by an energy storage member, with seal members configured to fluidically isolate the gas chamber.
Gas chamber housing with seal members that isolate the gas chamber
A housing defining a gas chamber; a first seal member in sliding contact with an inner surface of the housing to fluidically isolate the gas chamber; and additional seal member(s) positioned within a recess and/or surrounding portions of the carrier assembly or in contact with defined inner surfaces so the gas chamber remains fluidically isolated.
Energy-storage-driven carrier movement defining needle exposure positions
A carrier assembly coupled to the medicament container assembly, configured to move within the housing from a first carrier position to a second carrier position in response to actuation of an energy storage member or in response to a force exerted on an outer surface by pressurized gas, where the needle is disposed within the housing in the first carrier position and a portion of the needle is disposed outside of the housing in the second carrier position.
Carrier shoulder and recess receiving seal member(s) at the flange region
A carrier body defining an internal volume sized to receive a portion of the container body or syringe body and having a shoulder defining a recess, where a second/third seal member is positioned at least partially within the recess and is in contact with a proximal end portion of the container body or an inner surface of the carrier assembly, the shoulder, the syringe body and a distal-most surface of a flange assembly.
Prefilled syringe assembly with elastomeric member and needle staked to distal end
A prefilled syringe assembly disposed within the housing, including a syringe body and an elastomeric member disposed within the syringe body, with a needle staked to a distal end portion of the syringe body.
Pressurized gas generated in the gas chamber by an energy storage member
An energy storage member configured to produce a pressurized gas within the gas chamber when the energy storage member is actuated, the pressurized gas exerting a force on the carrier assembly to move the carrier body between the first carrier position and the second carrier position.
The independent claim set is centered on a gas-chamber medicament delivery apparatus where an energy storage member drives a carrier assembly between positions that control needle exposure, while seal members configured for sliding contact and recess positioning fluidically isolate the gas chamber from the medicament container interface.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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