Methods and compositions for wound healing
Inventors
Agarwal, Ankit • Pranami, Gaurav • Nelson, Tyler B. • O'Keefe, Anna M. • Abbott, Nicholas L. • Crawford, Eric
Assignees
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Publication Number
US-12409247-B2
Publication Date
2025-09-09
Expiration Date
Abstract
The present invention relates to large scale manufacture of nanoscale microsheets for use in applications such as wound healing or modification of a biological or medical surface.
Core Innovation
The invention relates to an article that includes a flexible substrate having a surface with a release coating selected from silicone, polydimethyl siloxane (PDMS), fluorocarbon, polyacrylate, polystyrene, polystyreneacrylic, chromium stearate complex, and polyolefin coatings. The flexible substrate is in communication with a roll and has a total surface area greater than 0.65 square meters. A nanoscale polymer multilayer is adjacent to and in contact with the surface of the flexible substrate.
The article further includes a sacrificial polymer layer adjacent to and in contact with the nanoscale polymer multilayer, such that the nanoscale polymer multilayer is between the substrate surface and the sacrificial polymer layer. The sacrificial polymer layer is dissolvable or biodegradable and has a thickness of from 0.2 bcm to 1000 bcm. The nanoscale polymer multilayer has a thickness of from 0.5 nm to 10000 nm.
The article incorporates a bioactive agent into the nanoscale polymer multilayer, where the bioactive agent is interspersed within a three dimensional structure of the nanoscale polymer multilayer or interspersed within the layers of the polymer multilayer. The bioactive agent is selected from antimicrobial agent, antibiofilm agent, growth factor, hemostatic agent, bioactive peptide, bioactive polypeptide, analgesic, local anesthetic, opioid, opioid antagonist or mixed agonist/antagonist, anticoagulant, anti-inflammatory agent, and drug molecule or drug compound.
Claims Coverage
The document identifies one independent claim directed to an article including a flexible roll-based substrate with a selected release coating, carrying a nanoscale polymer multilayer with a dissolvable or biodegradable sacrificial polymer layer and an incorporated bioactive agent. The independent claim is supported by dependent claims that refine polyelectrolyte selection, multilayer formation, sacrificial-layer behavior, and polymer composition.
Roll-based flexible substrate with selectable release coating and defined surface area
A flexible substrate in communication with a roll, having a surface with a release coating selected from silicone coating, a polydimethyl siloxane (PDMS) coating, a fluorocarbon coating, a polyacrylate coating, a polystyrene coating, a polystyreneacrylic coating, a chromium stearate complex coating, and a polyolefin coating and having a total surface area greater than 0.65 square meters.
Nanoscale polymer multilayer in contact with the release-coated substrate
A nanoscale polymer multilayer adjacent to and in contact with the surface, with a thickness of from 0.5 nm to 10000 nm thick.
Dissolvable or biodegradable sacrificial polymer layer adjacent to the nanoscale multilayer
A sacrificial polymer layer adjacent to and in contact with the nanoscale polymer multilayer so that the nanoscale polymer multilayer is between the surface of the substrate and the sacrificial polymer layer, wherein the sacrificial polymer layer is dissolvable or biodegradable and is from 0.2 bcm to 1000 bcm thick.
Bioactive agent incorporated in a three dimensional nanoscale polymer multilayer structure
A bioactive agent incorporated into the nanoscale polymer multilayer, wherein the bioactive agent is interspersed within the three dimensional structure of the nanoscale polymer multilayer or interspersed within the layers of the polymer multilayer and wherein the bioactive agent is selected from the group consisting of an antimicrobial agent, an antibiofilm agent, a growth factor, a hemostatic agent, a bioactive peptide, a bioactive polypeptide, an analgesic, a local anesthetic, an opioid, an opioid antagonist or mixed agonist/antagonist, an anticoagulant, anti-inflammatory agent, and a drug molecule or a drug compound.
Alternating positively and negatively charged polyelectrolyte multilayer architecture
The nanoscale polymer multilayer is made of alternating positively charged and negatively charged polyelectrolyte layers.
Multilayer formation using specified coating or printing methods
Forming the nanoscale polymer multilayer by applying at least one positively charged polyelectrolyte and at least one negatively charged polyelectrolyte using one of multiple specified coating or printing methods including spray, dip, spin, slot die, inkjet, gravure/rotogravure, roll-to-roll, blade/knife/air-knife/curtain, melt extrusion, solvent casting, and combinations thereof.
Sacrificial layer reducing bioactive agent release by a quantified factor
The sacrificial polymer layer reduces the release of a bioactive agent from a nanoscale multilayer by 1 to 1000 times.
Sacrificial polymer layer selected from a defined polymer group
The sacrificial polymer layer is made from a polymer selected from a group including PVA, PAA, PVP, CMC, and other listed polymers.
Across the independent claim and its refinements, the inventive subject matter centers on a roll-based flexible substrate with a selected release coating carrying a nanoscale polymer multilayer of defined thickness, coupled with an adjacent dissolvable or biodegradable sacrificial polymer layer of defined thickness, and a bioactive agent incorporated within the multilayer structure. Dependent claims further refine the multilayer by requiring alternating positively and negatively charged polyelectrolytes, limiting how the polyelectrolyte layers are applied, constraining the degree of bioactive-agent release reduction, and specifying a set of polymers for the sacrificial layer.
Stated Advantages
Documented Applications
No documented applications found
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