System and method to induce epigenetic changes to the cells and tissue of the eye and orbit
Inventors
Humayun, Mark S. • Lazzi, Gianluca • Salhia, Bodour • Machnoor, Manjunath • Paknahad, Javad
Assignees
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Publication Number
US-12403311-B2
Publication Date
2025-09-02
Expiration Date
Abstract
Methods, systems, and apparatus for causing changes to cells or tissue within or adjacent to an eye. The system includes an external RF coil configured to transmit RF signals. The system also includes a wearable device configured to be removably disposed on the eye, the wearable device including a plurality of internal radiofrequency (RF) coils configured to receive the RF signals from the external RF coil and a plurality of stimulating electrodes configured to electromagnetically stimulate a portion of the eye or an area adjacent to the eye, causing changes to cells or tissue within or adjacent to the eye.
Core Innovation
The patent describes a system that includes an external radiofrequency (RF) coil configured to transmit RF signals toward an eye of a user, with the external RF coil spaced apart from the eye when transmitting the RF signals. The system further provides a wearable device that is removably disposed on the eye and includes a curved material having an aperture located at a center of the curved material to allow for corneal oxygenation. Internal RF coils located on or within the curved material receive the RF signals from the external RF coil and are electrically connected to stimulating electrodes.
The stimulating electrodes include a positive electrode and a negative electrode that are electrically connected to the internal RF coils. The positive electrode is positioned on the curved material and is configured to electromagnetically stimulate a retina of the eye, causing changes to cells or tissue of the eye or causing changes to cells or tissue adjacent to the eye. The wearable device is also described as defining the electrode arrangement with respect to inner and outer surfaces of the curved material.
The patent also describes a transcorneal electrical stimulation system using an external RF coil that transmits RF signals to a removably worn, curved ocular device with internal RF coils and stimulating electrodes. In this system, the curved material defines an aperture located at the center of the curved material for corneal oxygenation, and the stimulating electrodes include a ground electrode located on an outer surface, a negative electrode located on an inner surface or an outer surface, and a positive electrode located on an inner surface configured to electromagnetically stimulate a portion of the eye or an area adjacent to the eye.
Claims Coverage
The provided independent claims are clm-00001 and clm-00011. Across these claims, the coverage is organized around two main inventive feature sets: an external RF coil spaced from the eye driving a removable curved ocular device with internal RF coils and electrode-driven electromagnetic stimulation causing cellular/tissue changes, and the more specific transcorneal electrical stimulation architecture using a curved ocular device with inner/outer electrode placement and a corneal oxygenation aperture.
External RF coil spaced apart from the eye and wearable curved device with corneal oxygenation aperture
An external radiofrequency (RF) coil configured to transmit RF signals toward an eye of a user, the external RF coil configured to be spaced apart from the eye of the user when transmitting the RF signals; and a wearable device including a curved material configured to be removably disposed on the eye and having an aperture located at a center of the curved material to allow for corneal oxygenation.
Internal RF coils receiving external RF signals and electrode-driven electromagnetic stimulation causing cellular/tissue changes
A plurality of internal RF coils located on or within the curved material and configured to receive the RF signals from the external RF coil; and a plurality of stimulating electrodes including a positive electrode and a negative electrode electrically connected to the plurality of internal RF coils, the positive electrode positioned on the curved material and configured to electromagnetically stimulate a retina of the eye, causing changes to cells or tissue of the eye or causing changes to cells or tissue adjacent to the eye.
Transcorneal electrical stimulation with external RF coil and removable curved ocular device defining inner/outer electrode surfaces and corneal oxygenation aperture
An external radiofrequency (RF) coil configured to transmit RF signals; and a wearable device configured to be removably disposed on an eye of a user, the wearable device including a curved material configured to be removably placed on the eye, the curved material having an inner surface and an outer surface, the inner surface configured to removably contact the eye, the curved material defining an aperture located at a center of the curved material to allow for corneal oxygenation.
Ground/negative/positive electrode placement on inner/outer surfaces with electrode-driven stimulation of portion of the eye or adjacent area
A plurality of internal RF coils located within the curved material and configured to receive the RF signals from the external RF coil; and a plurality of stimulating electrodes electrically connected to the plurality of internal RF coils, the plurality of stimulating electrodes including a ground electrode located on the outer surface of the curved material, a negative electrode located on the inner surface or the outer surface of the curved material, and a positive electrode located on the inner surface of the curved material and configured to electromagnetically stimulate a portion of the eye or an area adjacent to the eye, causing changes to cells or tissue of the eye or causing changes to cells or tissue adjacent to the eye.
Across clm-00001 and clm-00011, the claims cover driving a removably worn curved ocular device with external RF signals using internal RF coils, while corneal oxygenation is provided by an aperture in the curved material. Electrode configurations with positive/negative and optionally ground electrodes positioned on inner and/or outer surfaces are configured to electromagnetically stimulate a portion of the eye (including the retina) or an area adjacent to the eye, causing changes to cells or tissue of the eye or adjacent cells or tissue.
Stated Advantages
Corneal oxygenation is allowed through an aperture located at a center of the curved material.
The system is configured to electromagnetically stimulate a retina of the eye or a portion of the eye or an area adjacent to the eye, causing changes to cells or tissue of the eye or adjacent cells or tissue.
Documented Applications
Electromagnetically stimulating a retina of the eye, causing changes to cells or tissue of the eye or adjacent cells or tissue.
Electromagnetically stimulating a lacrimal gland for treatment of dry eye.
The transcorneal electrical stimulation system is configured to electromagnetically stimulate a portion of the eye or an area adjacent to the eye, causing changes to cells or tissue of the eye or adjacent cells or tissue.
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