Interested in licensing this patent?
MTEC can help explore whether this patent might be available for licensing for your application.
Publication Number
US-12377204-B2
Publication Date
2025-08-05
Expiration Date
Abstract
A method for collecting plasma includes determining the weight, height, and hematocrit of a donor, and calculating a donor plasma volume and a target plasma collection volume. The target plasma collection volume is based on the donor plasma volume and a target percentage of plasma. The method then withdraws blood from the donor through a line connected to a blood component separation device, and introduces anticoagulant into the withdrawn blood. The blood component separation device separates the blood into a plasma component and a second blood component, and the plasma component is collected from the blood component separation device and into a plasma collection container. The method may then calculate the volume of pure plasma collected within the plasma collection container, and continue processing/collecting until the calculated volume of pure plasma equals the target plasma collection volume.
Core Innovation
Plasma collection methods and systems estimate pure plasma volume by accounting for anticoagulant mixed into the collected product, using donor hematocrit and anticoagulant-volume measurements, and stopping collection at a pure-plasma target. The claims also describe calculating a donor-tailored target from donor total blood volume, which is based at least in part on donor weight and height, and the donor's hematocrit.
The system includes a blood component separation device, pumps, a controller, and optional container-weight, anticoagulant, and optical sensors; returned separator contents and saline may be controlled to reach a target intravascular deficit. The provided partial content does not include the background section, so the problem stated there is not explicitly described.
Claims Coverage
The provided relevant claims identify four independent claims: two methods and two systems for collecting plasma. The four inventive features below summarize the principal claim elements of each independent claim.
Donor-tailored plasma collection method with a target stopping condition
Claim 1 calculates donor total blood volume based at least in part on donor weight and height, then calculates a donor-tailored target plasma amount based at least in part on that volume and donor hematocrit. The method separates withdrawn whole blood into a plasma component and at least a second blood component, and collects plasma until the target amount is reached in the plasma collection container.
Plasma collection system with a donor-tailored target calculation
Claim 8 covers a system with a venous-access device, blood component separation device, first line controlled by a first pump, anticoagulant line, and controller. The controller calculates a donor-tailored target plasma amount based at least in part on donor total blood volume and hematocrit, with total blood volume based at least in part on donor weight and height.
Individualized plasma collection method
Claim 15 determines donor weight, height, and hematocrit, calculates donor total blood volume based at least in part on weight and height, and calculates a target plasma amount based at least in part on total blood volume and hematocrit. The target is tailored to the donor's individual characteristics, and the method collects the separated plasma component into a plasma collection container.
Plasma collection system receiving donor characteristics
Claim 23 covers a plasma collection system whose controller receives donor weight, height, and hematocrit and calculates a target plasma amount tailored to those individual characteristics. The calculation is based at least in part on donor total blood volume and hematocrit, with total blood volume based at least in part on weight and height.
The independent claims cover donor-tailored plasma collection methods and systems. Their central claim elements are the calculation of a target plasma amount from donor characteristics and the separation and collection of plasma; certain claims also specify a collection stopping condition.
Stated Advantages
The target plasma amount is characterized in dependent claims as an optimized safe amount to collect from the donor.
Documented Applications
Collecting plasma from a donor using a blood component separation device and a plasma collection container.
Interested in licensing this patent?