Embolic compositions and methods
Inventors
Groom, Jeffrey • WILTSEY, Craig • Pham, Quynh • MANSUKHANI, Nikhita • Guertin, Courtney • Core, Lee • Sharma, Upma
Assignees
Interested in licensing this patent?
MTEC can help explore whether this patent might be available for licensing for your application.
Publication Number
US-12370286-B2
Publication Date
2025-07-29
Expiration Date
Abstract
The present disclosure pertains to crosslinkable compositions and systems as well as methods for forming crosslinked compositions in situ, including the use of the same for embolizing vasculature including the neurovasculature within a patient, among many other uses.
Core Innovation
The invention provides a method of embolizing a hypervascular tumor in a patient by forming an injectable crosslinkable composition for vascular embolization. The crosslinkable composition is formed from a first fluid composition that includes a crosslinkable polymer and a first imaging agent with an average primary particle size of 80 nm to 200 nm, and a second fluid composition that includes a crosslinker and, optionally, a second imaging agent with an average primary particle size of 80 nm to 200 nm.
The method further forms the crosslinkable composition by mixing the first and second fluid compositions with a dry composition comprising a first silica filler and optionally a second silica filler that is the same as or different from the first silica filler. The first imaging agent, the second imaging agent, the first silica filler, and the optional second silica filler are dispersed in the crosslinkable composition.
After forming the crosslinkable composition, the invention prepares it for injection and injects it into an injection site within a vasculature of the hypervascular tumor. Upon injection, the crosslinkable composition substantially flows into and occludes a target vessel in the vasculature, and thereafter crosslinks and forms into a solid at the target vessel, producing embolization in the hypervascular tumor vasculature.
Claims Coverage
The independent claim is directed to a method of embolizing a hypervascular tumor in a patient using an injectable crosslinkable composition formed by combining two fluid compositions with a dry silica-containing composition. The inventive features emphasized in the independent claim are supported by dependent claims that narrow tumor and delivery context and further specify imaging agent loading, silica filler type, hydride chemistry, and mixing ratio between the first and second fluid compositions.
Embolizing a hypervascular tumor with an in situ crosslinking injectable composition
A method that forms a crosslinkable composition for vascular embolization, prepares it for injection, injects the composition into an injection site within tumor vasculature where it substantially flows into and occludes a target vessel, and whereafter the composition crosslinks and forms into a solid.
Two fluid composition crosslinking formulation with dispersed silica and imaging agents
Forming the crosslinkable composition by providing a first fluid composition with a crosslinkable polymer and a first imaging agent having an average primary particle size from 80 nm to 200 nm, providing a second fluid composition with a crosslinker and optionally a second imaging agent having an average primary particle size from 80 nm to 200 nm, and mixing the first fluid and second fluid with a dry composition comprising a first silica filler and optionally a second silica filler that is the same or different.
Dispersing imaging agents and silica fillers in the crosslinkable composition
Wherein the first imaging agent, the second imaging agent, the first silica filler, and the optional second silica filler are dispersed in the crosslinkable composition.
Across the independent claim, the core coverage is an embolization method for a hypervascular tumor that relies on forming and injecting a crosslinkable composition created from two fluid components containing crosslinkable polymer/crosslinker plus imaging agents with specified 80–200 nm primary particle size, and a dry silica-containing component to disperse silica fillers in the crosslinkable composition, followed by injection-driven flow into and occlusion of a target vessel and subsequent crosslinking into a solid.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
Interested in licensing this patent?