Embolic compositions and methods
Inventors
Groom, Jeffrey • WILTSEY, Craig • Pham, Quynh • MANSUKHANI, Nikhita • Guertin, Courtney • Core, Lee • Sharma, Upma
Assignees
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Publication Number
US-12370285-B2
Publication Date
2025-07-29
Expiration Date
Abstract
The present disclosure pertains to crosslinkable compositions and systems as well as methods for forming crosslinked compositions in situ, including the use of the same for embolizing vasculature including the neurovasculature within a patient, among many other uses.
Core Innovation
The invention provides solvent-free biocompatible in-situ crosslinkable embolic compositions and systems for forming and delivering crosslinked solids. The system uses a first suspension that comprises a first polysiloxane having two or more unsaturated groups and a first imaging agent, and a second suspension that comprises a first hydride material having two or more hydride groups and a second imaging agent which is the same or different from the first imaging agent. The separate components are stable prior to mixing and, when mixed, form a crosslinkable composition with the first and second imaging agents dispersed within the crosslinkable composition.
The invention further includes a dry composition comprising a first silica filler and optionally a second silica filler which is the same or different from the first silica filler. The crosslinkable composition cures into a solid when injected into a target vessel and occludes the target vessel. The described compositions and systems are emphasized for vascular embolization and neurovascular embolization, including in situ formation of a crosslinked solid during delivery.
The disclosure links the composition design to delivery and occlusion behavior, including shear-thinning and controlled viscosity recovery that supports injection and casting in vessels. It also describes distal penetration behavior and occlusion progression associated with catheter delivery, and includes imaging via radiopaque agents such as bismuth oxide and bismuth trioxide.
Claims Coverage
The partial content provides one independent claim, directed to a kit architecture for forming crosslinkable compositions for vascular embolization. The claim requires three stable components: a first suspension, a second suspension, and a dry silica composition, that together form a crosslinkable composition that cures into a solid after injection to occlude a target vessel. Dependent claims refine imaging agent identity and additional compositional constraints and delivery implementation.
Stable three-part kit for crosslinkable vascular embolic composition
A kit comprising a stable first suspension with a first polysiloxane having two or more unsaturated groups and a first imaging agent, a stable second suspension with a first hydride material having two or more hydride groups and a second imaging agent which is the same or different from the first imaging agent, and a stable dry composition comprising a first silica filler and optionally a second silica filler that is the same or different from the first silica filler, wherein mixing forms a crosslinkable composition with dispersed first and second imaging agents.
In situ curing into an occluding solid upon injection
A crosslinkable composition that cures into a solid when injected into a target vessel and occludes the target vessel.
Catheter delivery component for embolic curing and occlusion
The kit includes a component for delivering the crosslinkable composition, implemented as a catheter.
Claim coverage centers on a stable kit that separates crosslinking components into a first polysiloxane-based suspension and a second hydride-based suspension together with a separate dry silica filler, so that mixing produces an imaging agent-containing crosslinkable composition. The claim requires that, after injection into a target vessel, the composition cures into a solid and occludes the vessel, with delivery implemented as a catheter in the dependent claim set referenced in the partial content.
Stated Advantages
Enables a crosslinkable composition that cures into a solid when injected into a target vessel to occlude the target vessel.
Provides imaging through inclusion of first and second imaging agents dispersed in the crosslinkable composition.
Supports solvent-free biocompatible in-situ crosslinkable embolic compositions and systems.
Documented Applications
Vascular embolization.
Neurovascular embolization.
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