Molecular profiling of tumors
Inventors
Von Hoff, Daniel D. • Loesch, David M. • Alarcon, Arlet • Penny, Robert J. • Wright, Alan • McGinniss, Matthew J. • Bender, Ryan P. • Pawlowski, Traci
Assignees
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Publication Number
US-12366585-B2
Publication Date
2025-07-22
Expiration Date
Abstract
Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease.
Core Innovation
A computer system obtains data indicative of results of one or more molecular tests for a plurality of molecular profiling targets from a biological sample obtained from a patient that has a particular cancer type. The system accesses, without using the particular cancer type, a database to obtain corresponding reference values, and compares the obtained data to the corresponding reference values, where the corresponding reference values are not associated with the particular cancer type in the database as part of the comparing.
From the comparing, the system identifies at least one therapeutic agent based on an indication that the comparison indicates a likely benefit to the patient, and the identifying is performed without using the particular cancer type. The system generates a patient profile report that presents the identified at least one therapeutic agent as a suitable agent for the patient, and the at least one therapeutic agent includes a treatment not associated with treating the particular cancer type.
The system provides the patient profile report to an end user. In one described aspect, the method includes administering at least one of the identified therapeutic agents, including a therapeutic agent selected from a chemotherapeutic or hormonal treatment regimen.
Claims Coverage
The partial content provides three independent claims. Across these claims, the coverage centers on obtaining molecular test data for multiple molecular profiling targets, comparing them to reference values that are not associated with the particular cancer type, selecting therapeutic agents expected to likely benefit the patient without using the particular cancer type, and generating and providing a patient profile report that includes at least one treatment not associated with treating the particular cancer type.
Cancer-type-independent reference comparison of molecular test data
Obtaining data indicative of results of one or more molecular tests for a plurality of molecular profiling targets from a biological sample obtained from a patient that has a particular cancer type, accessing reference values without using the particular cancer type, and comparing the obtained data to corresponding reference values where the reference values are not associated with the particular cancer type in the database as part of the comparing.
Therapeutic agent identification based on likely benefit without using cancer type
Accessing the database or another database without using the particular cancer type to identify, from the comparing, at least one therapeutic agent based on an indication that the comparison indicates a likely benefit to the patient of the at least one therapeutic agent, wherein the identifying is performed without using the particular cancer type.
Patient profile report presenting suitable non-cancer-type treatment
Generating a patient profile report that presents the identified at least one therapeutic agent as a suitable agent for the patient, wherein the at least one therapeutic agent includes a treatment not associated with treating the particular cancer type, and providing the patient profile report to an end user.
Administering identified chemotherapeutic or hormonal regimen therapy
Administering at least one of the at least one therapeutic agent to the patient, wherein the administered at least one therapeutic agent includes a therapeutic agent selected from a chemotherapeutic or hormonal treatment regimen.
The independent claims cover computer system and computer-implemented operations that compare molecular test results to cancer-type-independent reference values, identify therapeutic agents indicated as likely beneficial without using the particular cancer type, and generate a patient profile report that includes at least one therapy not associated with treating the patient’s particular cancer type; one claim further includes administering at least one identified agent selected from chemotherapeutic or hormonal regimens.
Stated Advantages
Enables identification of therapeutic agents based on molecular test comparisons indicating a likely benefit to the patient.
Generates a patient profile report presenting therapeutic agents as suitable, including treatments not associated with treating the particular cancer type.
Documented Applications
Providing a patient profile report to an end user to support treatment selection based on molecular test results for a patient with a particular cancer type.
Administering at least one therapeutic agent to the patient where the administered agent includes a chemotherapeutic or hormonal treatment regimen.
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