Sensor for a continuous biological monitor having nitric oxide releasing compound
Inventors
Yan, Qinyi • Boock, Robert James • Haskamp, Jessie • Zhang, Huashi
Assignees
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Publication Number
US-12357207-B2
Publication Date
2025-07-15
Expiration Date
Abstract
A subcutaneous sensor for use with a continuous glucose monitor includes a working electrode and a reference electrode. The reference electrode comprises a reference substrate, an ion limiting layer over the reference substrate and a composition for releasing nitric oxide (NO). The composition has a NO release compound, a hydrophilic material and a hydrophobic material. A subcutaneous sensor for use with a continuous glucose monitor includes a reference electrode comprising a composition for releasing nitric oxide (NO). The composition has a NO release compound, a hydrophilic material and a hydrophobic material. The reference electrode is positioned separate from a working electrode.
Core Innovation
The invention relates to a subcutaneous sensor for use with a continuous glucose monitor, including a working electrode and a reference electrode positioned separate from the working electrode. The reference electrode comprises a reference substrate and an ion limiting layer over the reference substrate, and includes a composition for releasing nitric oxide (NO) having a NO release compound, a hydrophilic material, and a hydrophobic material.
The NO-releasing composition is arranged in relation to the reference electrode, including in and/or between reference electrode layers, such as with a paste and/or in the ion limiting layer and/or as a reference outer layer. This configuration is stated to reduce NO-working-reaction cross-interference and to improve immunity/foreign-body response tolerance and sensor stability/sensitivity over extended wear.
In the continuous glucose monitor sensor, the working electrode includes sensing layers for glucose measurement that include an interference membrane, an enzyme membrane for reacting with in-vivo glucose in body fluid, including hydrogen peroxide (H2O2) formed with glucose oxidase (GOx), and a glucose limiting layer for controlled glucose transport to the enzyme layer. The sensor also includes an interference layer on the working electrode to regulate ion/peroxide transport and improve signal-to-noise.
Claims Coverage
The document provides two independent claims covering a subcutaneous sensor for use with a continuous glucose monitor, with a working electrode and a reference electrode positioned separate from the working electrode, and a reference electrode that includes an NO-releasing composition comprising a NO release compound, a hydrophilic material, and a hydrophobic material. Across the independent claims, the core inventive features are the separated electrode arrangement and the defined three-component NO composition at the reference electrode.
Subcutaneous sensor with no-releasing reference electrode using no release compound, hydrophilic material, and hydrophobic material
A subcutaneous sensor for use with a continuous glucose monitor includes a working electrode and a reference electrode comprising a reference substrate, an ion limiting layer over the reference substrate, and a composition for releasing nitric oxide (NO) with a NO release compound, a hydrophilic material, and a hydrophobic material.
Separate reference electrode carrying no-releasing composition in a continuous glucose monitor
A subcutaneous sensor for use with a continuous glucose monitor includes a composition for releasing nitric oxide (NO) having a NO release compound, a hydrophilic material, and a hydrophobic material, wherein the reference electrode is positioned separate from a working electrode of the subcutaneous sensor.
Overall, claim coverage centers on a subcutaneous continuous glucose monitoring sensor with a reference electrode that includes an ion-limiting layer on a reference substrate and carries an NO-releasing composition comprising a NO release compound plus a hydrophilic and hydrophobic material, with the reference electrode positioned separate from the working electrode.
Stated Advantages
Reduces NO-working-reaction cross-interference.
Improves immunity/foreign-body response tolerance.
Improves sensor stability and sensitivity over extended wear.
Improves signal-to-noise ratio.
Documented Applications
Subcutaneous continuous glucose monitoring (CGM) sensor for use with a continuous glucose monitor.
Use in a continuous glucose monitor system having a working electrode and a reference electrode positioned separate from each other.
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