Lipid body compositions, products made therefrom, methods of making same, and methods of use
Inventors
Jeffries, Thomas W. • Kelleher, Thomas J. • Mokry, David Z. • Taylor, Richard • Gluth, Austin • Goldenberg, Merrill S.
Assignees
Interested in licensing this patent?
MTEC can help explore whether this patent might be available for licensing for your application.
Publication Number
US-12350364-B2
Publication Date
2025-07-08
Expiration Date
Abstract
The invention provides lipid bodies isolated from yeast, compositions comprising the lipid bodies, products made from the lipid bodies, methods of making the lipid bodies, and methods of using the lipid bodies. The lipid bodies of the invention have an exceptionally large size and high internal neutral lipid content, providing a number of advantages for a variety of practical applications.
Core Innovation
The invention relates to yeast-derived isolated lipid bodies in which each lipid body comprises an envelope surrounding an inner core. The envelope comprises phospholipid, protein, and polysaccharide, and the inner core comprises lipid. The isolated yeast lipid bodies are non-synthetic and include yeast protein associated with the lipid bodies, including a protein having an amino acid sequence at least 95% identical to SEQ ID NO:41.
The isolated yeast lipid bodies comprise a set of lipid bodies having a diameter of at least 5 μm. The lipid bodies are characterized by size distribution and percent fractions, core lipid weight percentages, and melting behavior, and can be present as merged or unmerged lipid bodies.
The invention further describes quality and color measurement based on absorbance at 400 nm, including crude and water-washed engineered yeast lipid bodies, and purified lipid bodies with residual color and whiteness/QC considerations. Processing and recovery of the lipid bodies are described from engineered hyper-lipogenic recombinant yeasts, and the resulting compositions are described as having functional behavior distinct from liposomes.
Claims Coverage
The independent claim covers a composition comprising isolated non-synthetic yeast lipid bodies having at least 5 μm diameter, with an envelope comprising phospholipid, protein, and polysaccharide and an inner lipid core, and requiring yeast protein with an amino acid sequence at least 95% identical to SEQ ID NO:41. The main inventive concept includes three inventive features.
Isolated yeast lipid bodies with phospholipid/protein/polysaccharide envelope and lipid inner core
A composition comprising isolated yeast lipid bodies where each lipid body comprises an envelope surrounding an inner core, the envelope comprises phospholipid, protein, and polysaccharide, and the inner core comprises lipid.
Non-synthetic lipid bodies having diameter at least 5 μm
The lipid bodies comprise a set of lipid bodies having a diameter of at least 5 μm and the lipid bodies are non-synthetic.
Yeast protein component defined by sequence identity to SEQ ID NO:41
The lipid bodies comprise yeast protein, wherein the yeast protein comprises a protein comprising an amino acid sequence at least 95% identical to SEQ ID NO:41.
The claim coverage is anchored in the structural definition of yeast lipid bodies, the non-synthetic nature with a minimum diameter of at least 5 μm, and the presence of yeast protein defined by at least 95% sequence identity to SEQ ID NO:41.
Stated Advantages
High hydrophobic loading capacity.
Smooth non-greasy aqueous feel.
Post-application sealing films.
Stability (pH/heat/autoclave tolerance).
Non-greasy, smooth, and soft sensory properties for topical protective formulations.
Protective skin coating and barrier effects, including a hydration or moisture barrier.
Reduced itching and irritation.
Support for healing and abrasions.
Stability as emulsions and suspensions in protective compositions.
UV absorbance and sunblock functionality described in the document.
Documented Applications
Cosmetic application, including skin cream/topical application.
Pharmaceutical application.
Oral application.
Inhaled application.
Wound application.
Industrial application.
Hair conditioner applications described as protective or emollient use.
Hand cream applications described as protective formulations.
Face cream applications described as protective formulations.
Therapeutic skin applications described as reduced itching and irritation and support for healing and abrasions.
Drug loading and release applications described.
UV absorption and sunblock applications described.
Sealing protective film or pancaked envelope-like sealing protective film applications described.
Industrial or lubricant applications described via solid or semi-solid waxy byproducts and related compositions.
Interested in licensing this patent?