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Publication Number
US-12350046-B2
Publication Date
2025-07-08
Expiration Date
Abstract
In one embodiment, a sensor is disclosed that includes a first conductive substrate coupled to, and electrically isolated from, a second conductive substrate. The sensor includes a first electrode trace within the first conductive substrate with a plurality of first working electrode openings. The sensor also includes a second electrode trace within the first conductive substrate with a plurality of second working electrode openings. Additionally a first transport material is included that covers the plurality of first working electrode openings and a second transport material that covers the plurality of second working electrode openings. A third transport material covers, and forms a barrier between the first and the second transport material. The sensor additionally includes a counter-reference electrode that is formed on the second conductive substrate.
Core Innovation
The invention describes an in vivo multi-analyte electrochemical sensor architecture having a first conductive substrate coupled to, and electrically isolated from, a second conductive substrate. The first conductive substrate includes a first electrode trace and a second electrode trace formed with respective arrays of first and second working-electrode openings in an A-side insulator, while the second conductive substrate supports a counter-reference electrode.
The sensor further includes a first transport material covering the plurality of first working electrode openings and a second transport material covering the plurality of second working electrode openings. A third transport material covers the first transport material and the second transport material and forms a barrier between the first transport material and the second transport material, and is configured to limit transmission of reaction byproducts and reduce crosstalk between the regions associated with the first and second transport materials.
Embodiments discuss reactive chemistries in connection with the working-electrode openings, including oxidase or dehydrogenase enzymes applied contiguously or discretely over the openings, and hydrogel transport layers enabling diffusion of analytes and reaction byproducts. The third transport material is described as an impermeable or impermeable/hydrophobic gas-permeable barrier used to reduce crosstalk and address oxygen-relative limitations without relying on limiting membranes, with target analytes including glucose, lactate, ketones, choline, and tissue oxygen.
Claims Coverage
The independent claim set out the overall multi-analyte electrochemical sensor architecture and includes at least five main inventive features. Dependent refinements further specify reactive chemistry placement, barrier selectivity against reaction products, hydrogel-based transport, and imperviousness of the barrier to at least one analyte.
Electrically isolated first and second conductive substrates with patterned electrode traces
A first conductive substrate is coupled to, and electrically isolated from, a second conductive substrate, with a first electrode trace and a second electrode trace formed from the first conductive substrate, the first and second electrode traces including respective pluralities of working-electrode openings formed in an A-side insulator.
Transport-material regions covering respective working-electrode openings
A first transport material covers the plurality of first working electrode openings and a second transport material covers the plurality of second working electrode openings.
Third transport barrier spanning and separating first and second transport materials
A third transport material covers the first transport material and the second transport material, forming a barrier between the first transport material and the second transport material.
Counter-reference electrode on the second conductive substrate
A counter-reference electrode is formed on the second conductive substrate.
Barrier selectivity limiting transmission of reaction products and crosstalk
The barrier is impervious to reaction products generated by a first reactive chemistry and reaction products generated by a second reactive chemistry.
Hydrogel transport material enabling analyte transport
The first transport material is a hydrogel configured to enable transport of a first analyte to the first reactive chemistry.
Imperviousness of the third transport material to at least one analyte
The third transport material is impervious to at least one of the first analyte or the second analyte.
The key inventive coverage centers on a two-substrate, electrically isolated multi-analyte electrochemical sensor with separate electrode-opening arrays in an A-side insulator, distinct first and second transport-material regions, and a third transport-material barrier spanning and separating the regions while limiting reaction byproducts and crosstalk. Additional dependent coverage specifies reactive chemistries, barrier selectivity against reaction products, hydrogel-based transport enabling analyte transport, and imperviousness of the third transport material to at least one analyte.
Stated Advantages
Reduces crosstalk between multi-analyte regions.
Addresses oxygen-relative limitations without relying on limiting membranes.
Documented Applications
In vivo multi-analyte electrochemical sensing of target analytes including glucose, lactate, ketones, choline, and tissue oxygen.
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