Pipetting support device, use thereof and method for pipetting liquid
Inventors
Assignees
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Publication Number
US-12343729-B2
Publication Date
2025-07-01
Expiration Date
Abstract
The present disclosure is directed to a device for supporting manual pipetting of liquids, to the use of such a pipetting support device, and to a method for pipetting liquid, for example from a number of first vessels to a number of second vessels, wherein a moving unit is movable in relation to a first plate and at least partially covers the first plate during use of the pipetting support device, and at least one edge of the moving unit provides guidance to support a manual pipetting procedure from said first plate to said second plate, or vice versa.
Core Innovation
A pipetting support device and a method of using the pipetting support device are provided for pipetting liquid between at least one first plate and at least one second plate. The first plate includes at least one row of first vessels, and the second plate includes at least one row of second vessels. The pipetting support device comprises at least one moving unit holding the second plate and movable in relation to the first plate during use.
During use, the moving unit is movable in relation to the first plate and at least partially covers the first plate. At least one edge of the moving unit is an indicating edge for indicating a row of first vessels of the first plate to be pipetted by a user, and the moving unit is moved so the indicating edge indicates successive rows. This provides guidance to support a manual pipetting procedure between the first plate and the second plate.
The method comprises placing the first plate under the moving unit, moving the moving unit in relation to the first plate so the at least one edge indicates a first row of vessels, placing the second plate on or into the moving unit, manually pipetting liquid from the indicated row in the first plate to a row of vessels in the second plate, and moving the moving unit until the indicating edge indicates another row of vessels in the first plate. Multiple embodiments are described, including a slidable sledge-style moving unit, geometry that reduces contamination risk and maintains a constant short source-destination distance, optional sequential plate handling with plate replacement during repeated row-by-row pipetting, and an embodiment enabling omission of a cover when the second plate is a microfluidic device inlet row.
Claims Coverage
The independent claim provides a row-by-row manual pipetting method using a movable unit that partially covers the first plate and uses an indicating edge to guide which row is to be pipetted. The inventive features described in the independent claim are specialized further in dependent claims by refining device geometry, cover and additional indicating edges, and repeated operation including plate replacement.
Movable unit partially covering first plate
The at least one moving unit holding said second plate is movable in relation to said first plate and at least partially covers said first plate during use of the pipetting support device.
Indicating edge for selecting row of first vessels
At least one edge of the moving unit is an indicating edge for indicating a row of first vessels of the first plate to be pipetted by a user for providing guidance to support a manual pipetting procedure between said first plate and said second plate.
Sequential row-by-row manual pipetting with guided movement
The method comprises placing said first plate under the moving unit, moving the moving unit so said at least one edge indicates a first row of vessels, placing said second plate on or into the moving unit, manually pipetting liquid from said indicated row in the first plate to a row of vessels in said second plate, and moving the moving unit until said at least one edge indicates another row of vessels in said first plate.
Overall, the claim coverage centers on guided manual pipetting between row(s) of first vessels and row(s) of second vessels using a movable unit that partially covers the first plate and provides an indicating edge to select successive rows, with dependent claims refining the guidance mechanism, movement arrangement, and repeated plate handling.
Stated Advantages
Improved accuracy/error prevention by reduced risk of mixing up rows/vessels.
Protection against contamination.
Reduced pipetting distance and reduced stress during manual pipetting.
Cost-effective manufacture and cleaning.
Documented Applications
Manually pipetting liquid between a first plate and a second plate using guidance for selecting rows during a manual pipetting procedure.
Using the pipetting support device with a second plate configured as a microfluidic device inlet row, enabling omission of the cover.
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