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Publication Number
US-12343451-B2
Publication Date
2025-07-01
Expiration Date
Abstract
The present disclosure relates to methods of preparing personalized blood vessels, useful for transplantation with improved host compatibility and reduced susceptibility to thrombosis. Also provided are personalized blood vessels produced by the methods and use thereof in surgery.
Core Innovation
The invention relates to preparing a personalized blood vessel using a bioreactor that circulates a suspension or solution in a closed circuit. An acellular tubular scaffold having two ends is connected to the bioreactor so that fluid circulation occurs through the scaffold while preparing the personalized blood vessel.
The bioreactor is equipped with a peristaltic pump, a container having a sampling port, and first and second connectors connected to ends of the tubular scaffold. When the first and second connectors are connected to the two ends of the tubular scaffold, the peristaltic pump mediates circulation of the suspension or solution in a closed circuit for preparing the personalized blood vessel, and one or more sensors are provided for measuring glucose level.
The described approach includes contacting the acellular tubular scaffold with whole blood, including undiluted whole blood or a diluted whole-blood suspension, and monitoring and adjustment of environmental parameters and nutrient levels. Glucose level control is described, supported by in-line sensors/modules.
Claims Coverage
The independent claim identified includes two core inventive features tied to the bioreactor hardware arrangement and glucose sensing: peristaltic pump-driven closed-circuit circulation through a tubular scaffold using connectors to opposite ends, and one or more glucose-measuring sensors.
Peristaltic-pump closed-circuit bioreactor with tubular scaffold end connectors
A bioreactor comprising a peristaltic pump and a container having a sampling port, wherein first and second connectors are connected to the container and each connector is connected to an end of a tubular scaffold; when the connectors are connected to the two ends of the tubular scaffold, the peristaltic pump mediates circulation of a suspension or solution in a closed circuit for preparing a personalized blood vessel.
Glucose-level sensing in the bioreactor
The bioreactor further comprises one or more sensors for measuring glucose level.
Across the identified independent claim, the claim coverage centers on a closed-circuit peristaltic-pump circulation system using connectors at opposite ends of a tubular scaffold to prepare a personalized blood vessel, together with glucose measurement via one or more sensors.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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