Apparatus, systems and methods for transvascular access to the brain
Inventors
Assignees
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Publication Number
US-12343076-B2
Publication Date
2025-07-01
Expiration Date
Abstract
The present disclosure discusses a devices, systems and methods for transvascular, transvenous and/or transdural access, to the brain parenchyma, subarachnoid or subdural spaces. In some embodiments, the disclosed systems and methods may be used for local drug delivery, tissue biopsy, nanofluidic or microelectronic device/component delivery/insertion/implantation, in situ imaging, ablation of abnormal brain tissue and the like. Embodiments of the present disclosure include an access catheter system for extravascular procedures in the brain having an elongate, flexible tubular body, with at least one lumen extending axially there through between a proximal end, and a distal end. The access catheter system may include a side exit port and a distal end port. Further, the access catheter system may include a selective deflector positioned within the lumen configured to deflect a procedure catheter and permit a guide catheter.
Core Innovation
The disclosure describes an access catheter system and method for transvascular access to intracranial areas. An access catheter is introduced into a first vein of a subject, and the catheter includes an elongate tubular body with a lumen, a distal exit port at the distal end, and a side exit port in communication with the lumen. The side exit port is advanced to be placed adjacent to a target transvascular access site using a guidewire extending through the lumen.
The method includes puncturing a venous wall to create a puncture at the target transvascular access site. A fluid delivery catheter is then positioned through the lumen of the access catheter, out through the side exit port, and through the puncture. The fluid delivery catheter includes a fluid delivery lumen configured so that it extends between a proximal location external to the subject and a distal location in an extravascular subdural or subarachnoid space in the brain.
The distal segment of the fluid delivery lumen is placed in fluid communication with the extravascular subdural or subarachnoid space, while an intermediate portion of the fluid delivery lumen extends within vasculature. The disclosure further relates to configurations that include a selective deflector that differentially routes procedure catheters, and lateral expandable supports that position and anchor a side port against a cerebral vein wall while buffering backpropagating forces and supporting post-procedural hemostasis via tamponade and/or bioresorbable hemostatic materials.
Claims Coverage
The disclosure includes one independent claim describing a method of accessing intracranial areas, with dependent claims that refine venous target selection, puncture and expandable-structure mechanics, and downstream uses of the fluid delivery lumen. The independent claim covers placing a side exit port adjacent a target transvascular access site, puncturing a venous wall, and positioning a fluid delivery catheter so its distal fluid delivery lumen segment is in fluid communication with an extravascular subdural or subarachnoid space while an intermediate portion remains within vasculature.
Transvascular venous access using an access catheter with side and distal exit ports
Introducing an access catheter into a first vein of a subject, the access catheter comprising an elongate tubular body with a lumen extending therethrough, a distal exit port in communication with the lumen at a distal end, and a side exit port in communication with the lumen.
Adjacent placement of the side exit port at a target transvascular access site
Advancing the access catheter such that the side exit port is placed adjacent to a target transvascular access site with a guidewire extending through the lumen.
Venous wall puncture and fluid delivery catheter placement through the puncture into extravascular subdural or subarachnoid space
Puncturing a venous wall to create a puncture at the target transvascular access site; positioning a fluid delivery catheter through the lumen of the access catheter, out the side exit port, and through the puncture, the fluid delivery catheter comprising a fluid delivery lumen extending between a proximal location external to the subject and a distal location in an extravascular subdural or subarachnoid space in the brain.
Fluid communication with extravascular subdural/subarachnoid space while intermediate lumen remains in vasculature
Configuring the fluid delivery lumen so that it is in fluid communication with the extravascular subdural or subarachnoid space, and such that an intermediate portion of the fluid delivery lumen extends within vasculature of the subject.
Across the independent claim, the method is centered on transvascular venous access using an access catheter having both side and distal exit ports, placing the side exit port adjacent a target transvascular access site, puncturing the venous wall, and positioning a fluid delivery catheter so the distal fluid delivery lumen segment communicates with an extravascular subdural or subarachnoid space while an intermediate portion remains within vasculature.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Local drug delivery.
Brain biopsy.
In situ imaging with optical/fiber optic/sonographic concepts.
Ablation/energy delivery (including ablation/laser interstitial thermal therapy concepts).
Implantation of nanofluidic or microelectronic devices.
Wireless submillimeter deep brain stimulator delivery.
Biopotential sensing/stimulation arrays (electrocorticography) via implantable microelectrocorticography arrays.
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