Apparatus, systems and methods for transvascular access to the brain
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Publication Number
US-12343073-B2
Publication Date
2025-07-01
Expiration Date
Abstract
The present disclosure discusses a devices, systems and methods for transvascular, transvenous and/or transdural access, to the brain parenchyma, subarachnoid or subdural spaces. In some embodiments, the disclosed systems and methods may be used for local drug delivery, tissue biopsy, nanofluidic or microelectronic device/component delivery/insertion/implantation, in situ imaging, ablation of abnormal brain tissue and the like. Embodiments of the present disclosure include an access catheter system for extravascular procedures in the brain having an elongate, flexible tubular body, with at least one lumen extending axially there through between a proximal end, and a distal end. The access catheter system may include a side exit port and a distal end port. Further, the access catheter system may include a selective deflector positioned within the lumen configured to deflect a procedure catheter and permit a guide catheter.
Core Innovation
The disclosure describes neuroendovascular systems and methods for providing extravascular access to intracranial targets from an extracranial vein through a cerebral venous system without burr holes or craniotomy. An elongate access catheter includes an elongate tubular body with a lumen, a distal exit port, and a side exit port in communication with the lumen, and the catheter is advanced such that the side exit port is placed adjacent to a target transvascular access site while a guidewire extends through the lumen.
The method includes puncturing a venous wall to create a puncture at the target transvascular access site and endovascularly providing transvascular access to an extravascular access site in the subject from the extracranial vein via the lumen, the access catheter, and the side exit port and the puncture. The disclosure further describes creating a transdural puncture at the superior sagittal sinus over the brain via the lumen of the access catheter and the side exit port.
The access catheter is further characterized by selective luminal deflector structures that permit larger procedure catheters to exit laterally through the side exit port while smaller guide catheters, microcatheters, and guidewires pass distally through a distal exit port. Expandable extra-axial structures, including inflatable balloons and non-occlusive wire mesh configurations, are used to anchor, position the side exit port against the venous wall, and create tamponade for hemostasis, with post-procedure sealing using bioresorbable hemostatic material if needed.
Claims Coverage
The partial content provides two independent claims: a first independent method claim and a second independent method claim. Together they define an access-catheter-based workflow that places a side exit port adjacent a target transvascular access site and provides extravascular access, with one claim further specifying puncturing and an extravascular access site via the side exit port and puncture, and the other claim specifying a transdural puncture at the superior sagittal sinus via the lumen and the side exit port.
Cerebral venous delivery via side exit port to extravascular access
Introducing an access catheter into a portion of the cerebral venous system of a subject, the access catheter comprising an elongate tubular body with a distal end and a lumen, a distal exit port at the distal end in communication with the lumen, and a side exit port in communication with the lumen, advancing the access catheter so the side exit port is adjacent a target transvascular access site with a guidewire extending through the lumen, puncturing a venous wall at the target transvascular access site, and endovascularly providing transvascular access to an extravascular access site in the subject from an extracranial vein via the lumen, the access catheter, and the side exit port and the puncture.
Transdural puncture at the superior sagittal sinus via lumen and side exit port
Introducing an access catheter into a portion of the cerebral venous system of a subject, the access catheter comprising an elongate tubular body with a distal end and a lumen, a distal exit port at the distal end in communication with the lumen, and a side exit port in communication with the lumen, advancing the access catheter so the side exit port is adjacent a target transvascular access site with a guidewire extending through the lumen, and endovascularly creating a transdural puncture at the superior sagittal sinus of the subject over the brain via the lumen of the access catheter and the side exit port.
Across the two independent claims, the shared core coverage is placement of a side exit port adjacent a target transvascular access site using an access catheter in the cerebral venous system and providing extravascular access endovascularly via the catheter lumen and side exit port. One independent claim additionally requires puncturing a venous wall to create a puncture and enabling transvascular access via the side exit port and the puncture, while the other independent claim specifically defines a transdural puncture at the superior sagittal sinus over the brain via the lumen and the side exit port.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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