System for hypothermic transport of samples
Inventors
Anderson, Lisa Maria • Judson, Jared Alden
Assignees
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Publication Number
US-12342810-B2
Publication Date
2025-07-01
Expiration Date
Abstract
A system for the hypothermic transport of biological samples, such as tissues, organs, or body fluids. The system includes a self-purging preservation apparatus to suspend a sample in preservation fluid and perfuse a tissue with preservation fluid. The self-purging preservation apparatus is placed in an insulated transport container having a cooling medium. When assembled, the system allows for transport of biological samples for extended periods of time at a stable temperature.
Core Innovation
The invention provides a method for hypothermic transport of an organ by placing the organ inside an insert disposed within a transport container. The insert includes a plurality of vertically extending ribs that secure the insert to inside surfaces of the transport container and limit lateral movement, and the insert corresponds in size and shape to a perimeter of the interior of the transport container.
Eutectic cooling blocks are arranged along the inside surfaces of the transport container, and a lid is coupled with the transport container to form an insulated environment within the transport container. With the organ inside the insert and the insert disposed within the transport container, the organ is transported while the eutectic cooling blocks maintain a temperature within the transport container within an acceptable range.
The transport container is arranged to support maintaining a hypothermic temperature condition during transport using eutectic cooling blocks and an insulated environment formed with the lid. The document also discusses experimental comparisons of storage approaches for biological organs, including cold pulsatile storage versus static storage, to support preserving viability over extended transport time windows.
Claims Coverage
The independent claims cover a hypothermic transport method with three main inventive features: an insert secured by vertically extending ribs within a transport container, eutectic cooling blocks arranged along inside surfaces, and a lid that forms an insulated environment while transporting the organ with the container temperature maintained within an acceptable range.
Insert secured to limit lateral movement using vertically extending ribs
providing an insert inside the transport container, the insert comprising a plurality of vertically extending ribs configured to secure the insert to inside surfaces of the transport container, the plurality of vertically extending ribs configured to abut the inside surfaces of the transport container, the insert corresponding in size and shape to a perimeter of the interior of the transport container such that lateral movement of the insert is limited
Eutectic cooling blocks along inside surfaces
arranging eutectic cooling blocks along the inside surfaces of the transport container
Insulated environment formed by coupling a lid with the container
coupling a lid with the transport container to form an insulated environment within the transport container
Transport while eutectic cooling blocks maintain an acceptable temperature range
transporting the organ within the transport container while the eutectic cooling blocks maintain a temperature within the transport container within an acceptable range
Across the independent claims, the inventive coverage centers on an organ secured within an insert with limited lateral movement, a transport container carrying eutectic cooling blocks along its inside surfaces, and a lid that forms an insulated environment during transport while the eutectic cooling blocks maintain the container temperature within an acceptable range.
Stated Advantages
Maintains a temperature within the transport container within an acceptable range during transport using eutectic cooling blocks.
Enables hypothermic transport with extended time windows by maintaining acceptable temperature conditions for specified durations.
Documented Applications
Hypothermic transport of an organ for controlled transport using eutectic cooling blocks and an insulated transport container.
Cold pulsatile storage of canine kidneys versus static storage, with preserved viability and improved functional metrics reported for pulsatile storage up to 24 hours.
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