Compositions and methods for restoring or increasing tissue perfusion
Inventors
Mangino, Martin J. • Liebrecht, Loren K.
Assignees
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Publication Number
US-12337012-B2
Publication Date
2025-06-24
Expiration Date
Abstract
A composition for restoring or increasing tissue perfusion is provided. The composition includes polyethylene glycol polymers (PEG) with a molecular weight of 18,000-100,000 Da at a concentration of 5-20% by weight; PEG with a molecular weight of 1,000-10,000 Da at a concentration of 1-30% by weight; and water, wherein said PEG with a molecular weight of 18,000-100,000 Da and said PEG with a molecular weight of 1,000-10,000 Da are dissolved or dispersed in said water.
Core Innovation
The invention is an injectable aqueous composition combining therapeutic high-molecular-weight polyethylene glycol with lower-molecular-weight polyethylene glycol and water. The lower-molecular-weight polyethylene glycol inhibits erythrocyte sedimentation associated with the therapeutic polyethylene glycol. The high-molecular-weight component draws isotonic water from swollen cells and helps decompress capillaries, supporting restoration of microcirculatory perfusion.
The composition addresses reduced microcirculatory perfusion associated with metabolic cell swelling and capillary compression, alongside erythrocyte sedimentation associated with therapeutic polyethylene glycol. The formulation is utilized for shock resuscitation, where the high-molecular-weight component relieves capillary compression and the lower-molecular-weight component inhibits sedimentation. The aqueous composition is configured for intravenous administration.
Claims Coverage
The claims identify one independent claim encompassing three inventive features.
Combination of therapeutic and lower-molecular-weight polyethylene glycol
The independent claim covers an injectable composition containing therapeutic polyethylene glycol and lower-molecular-weight polyethylene glycol, with the latter included to inhibit erythrocyte sedimentation associated with the therapeutic polyethylene glycol.
Aqueous composition
The polyethylene glycols are dissolved in water to provide the claimed composition.
Composition configured for injection
The composition is configured to be delivered by injection.
The independent claim covers an injectable aqueous composition that combines therapeutic polyethylene glycol with lower-molecular-weight polyethylene glycol for inhibiting associated erythrocyte sedimentation.
Stated Advantages
The high-molecular-weight polyethylene glycol helps decompress capillaries and restore microcirculatory perfusion.
The lower-molecular-weight polyethylene glycol inhibits erythrocyte sedimentation associated with the therapeutic polyethylene glycol.
Rodent shock data identify improved resuscitation time, arterial pressure, and lactate outcomes with the reported polyethylene glycol compositions.
The composition may reduce blood requirements.
Documented Applications
Shock resuscitation, including use to restore or increase local or global tissue perfusion in subjects with reduced perfusion due to cardiogenic or noncardiogenic shock.
Use with cellular or acellular oxygen-carrier solutions during shock resuscitation.
Provision of the composition in an intravenous infusion bag.
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