Hyaluronic acid-based dissolving film, production method thereof, and release liner used for the same
Inventors
Kim, Jun Ho • CHO, Mi Ran • Lee, Hye Ri
Assignees
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Publication Number
US-12329860-B2
Publication Date
2025-06-17
Expiration Date
Abstract
The present invention relates to a hyaluronic acid-based dissolving film, a production method thereof, and a release liner used for the same, and more particularly to a method for producing a hyaluronic acid-based dissolving film that provides a hyaluronic acid-based dissolving film having high performance with high productivity through a continuous production process to allow mass production of the dissolving film, a hyaluronic acid-based dissolving film produced by the method, and a release liner suitable for the dissolving film.
Core Innovation
The invention relates to a continuous production method for a hyaluronic acid-based dissolving film. A hyaluronic acid-based solution is prepared to be carried on a continuous production line, a release paper is supplied to the continuous production line, and the hyaluronic acid-based solution is continuously applied on the upper side of a release liner supplied to the continuous production line.
The applied hyaluronic acid-based solution is dried on the continuous production line to form the hyaluronic acid-based dissolving film. A coating solution is applied on the upper side of the release paper, and the applied coating solution is dried prior to or after supplying the release paper to the continuous production line. The coating solution comprises 10 to 20 wt. % of polyvinyl acetate, 10 to 20 wt. % of water, 50 to 70 wt. % of ethanol, and 1 to 10 wt. % of polyvinyl pyrrolidone.
The hyaluronic acid-based solution comprises 18 to 26 wt. % of a hyaluronic acid-based compound, 0.2 to 0.6 wt. % of cellulose ether, 0.5 to 1.5 wt. % of polyvinyl alcohol, 0.2 to 0.6 wt. % of polyethylene glycol, 1 to 7 wt. % of polyvinyl pyrrolidone, and the hyaluronic acid-based compound has a weight average molecular weight of 10,000 to 50,000 g/mol. The approach is described as improving high performance and high productivity compared to batch casting and drying.
Claims Coverage
The document provides one independent claim covering a continuous production method for a hyaluronic acid-based dissolving film with an inline drying step and a separately applied and dried coating solution on the release paper, wherein both the hyaluronic acid-based solution and coating solution are constrained by specific compositions and molecular weight. Dependent claims further narrow the process by adding kiss-cutting, mesh or nonwoven lamination, release paper removal, winding, and specified application and drying conditions.
Continuous production using release liner with inline drying
Preparing a hyaluronic acid-based solution capable of being carried on a continuous production line; supplying a release paper to the continuous production line; continuously applying the hyaluronic acid-based solution on the upper side of a release liner supplied to the continuous production line; and drying the applied hyaluronic acid-based solution on the continuous production line to form a hyaluronic acid-based dissolving film.
Coating solution applied on release paper and dried prior to or after supplying
Applying a coating solution on the upper side of the release paper and then drying the applied coating solution prior to or after supplying the release paper to the continuous production line, wherein the coating solution comprises 10 to 20 wt. % polyvinyl acetate, 10 to 20 wt. % water, 50 to 70 wt. % ethanol, and 1 to 10 wt. % polyvinyl pyrrolidone.
Compositional constraints for hyaluronic acid-based solution with molecular weight
Forming the hyaluronic acid-based solution with 18 to 26 wt. % of a hyaluronic acid-based compound, 0.2 to 0.6 wt. % cellulose ether, 0.5 to 1.5 wt. % polyvinyl alcohol, 0.2 to 0.6 wt. % polyethylene glycol, 1 to 7 wt. % polyvinyl pyrrolidone, and requiring that the hyaluronic acid-based compound has a weight average molecular weight of 10,000 to 50,000 g/mol.
Claim coverage centers on a continuous production line process that continuously applies and inline-dries a hyaluronic acid-based solution on a release liner to form a hyaluronic acid-based dissolving film, combined with application and drying of a coating solution on the release paper. The process is further constrained by specific wt. % compositions for both solutions and by a weight average molecular weight range for the hyaluronic acid-based compound, with dependent claims adding kiss-cutting, mesh or nonwoven lamination, release paper removal, winding, and specified application and drying conditions.
Stated Advantages
Improved high performance and high productivity compared to batch casting and drying.
Documented Applications
Production of a hyaluronic acid-based dissolving film using a continuous production line with a release liner and a coating solution on the release paper.
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