Method and composition for enhancing the quality and benefits of sleep
Inventors
Nelson, Deanna J. • Komorowski, James R.
Assignees
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Publication Number
US-12329774-B2
Publication Date
2025-06-17
Expiration Date
Abstract
Compounds, compositions and methods of making and using for enhancing the quality and benefit of sleep and/or wakefulness in a subject in need thereof.
Core Innovation
The disclosed subject matter provides magnesium di-L-theanate compositions, wherein the magnesium di-L-theanate is characterized by an optical rotation of 3-4°. The disclosed composition is distinguished from a simple mixture and includes defined composition attributes for the solid form. The disclosure further characterizes the magnesium di-L-theanate by solubility and storage stability.
The disclosed subject matter addresses improving sleep quality and sleep parameters in mammals. Magnesium di-L-theanate is used to enhance sleep quality/wakefulness, including effects on sleep latency, sleep duration, and slow-wave sleep and associated EEG/spike activity. The reported outcomes include restoration of neurotransmitters and related measures in mammal models.
The disclosure reports neurotransmitter and neuroprotection-related effects associated with magnesium di-L-theanate in caffeine-induced wakefulness and pentobarbital-induced sleep rodent models. It reports restoration of serotonin, dopamine, and melatonin, antioxidant status as reflected by oxidative stress markers and antioxidant enzymes, and neuroprotection/apoptosis marker changes. It also reports preservation of neurotransmitter receptors, including GABA receptors and glutamate receptors.
Claims Coverage
The partial content includes two independent claims. The claims cover a composition defined by an optical rotation range for magnesium di-L-theanate, and a sleep-improvement method involving administering an effective amount of magnesium di-L-theanate with specified solid/product characteristics and sleep-parameter effects.
Magnesium di-L-theanate composition with defined optical rotation
A composition comprising magnesium di-L-theanate, wherein the magnesium di-L-theanate exhibits an optical rotation of 3-4°.
Administering magnesium di-L-theanate to improve sleep
A method of improving sleep in a subject in need thereof, comprising administering an effective amount of magnesium di-L-theanate, sufficient to decrease sleep latency and/or increase length of sleep, wherein the magnesium di-L-theanate is a solid having an optical rotation of 3-4° and contains 5.5-6.0% by weight magnesium and 94.0-94.5% by weight L-theanate.
Overall, the claim coverage centers on magnesium di-L-theanate defined by an optical-rotation characteristic, and on improving sleep by administering an effective amount of the defined magnesium di-L-theanate that is sufficient to decrease sleep latency and/or increase length of sleep while maintaining specified solid and composition attributes.
Stated Advantages
Decreases sleep latency and/or increases length of sleep.
Enhances sleep quality/wakefulness in mammals, including effects on slow-wave sleep and EEG/spike activity.
Restores neurotransmitters including serotonin, dopamine, and melatonin.
Improves antioxidant status as reflected by oxidative stress markers and antioxidant enzymes.
Provides neuroprotection-related effects, including changes in apoptosis/cell survival markers.
Preserves neurotransmitter receptor measures including GABA receptors and glutamate receptors.
Reportedly more effective than L-theanine alone in the described comparative outcomes.
Documented Applications
Improving sleep quality in a subject in need thereof by administering magnesium di-L-theanate, including use in caffeine-induced wakefulness mouse models and pentobarbital-induced sleep mouse models.
Use to enhance sleep parameters such as sleep latency, sleep duration, and slow-wave sleep, with EEG/spike activity effects, in mammal/rodent models described in the disclosure.
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