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Publication Number
US-12329613-B2
Publication Date
2025-06-17
Expiration Date
Abstract
The invention relates to electrically-heatable plasters which comprise a self-adhesive skin contact layer, an electrically-conductive textile fabric in which electrically-conductive fibres are in contact with one another, as a heating element, and optionally at least one active substance, as well as to a method for production and the use of same for local heat therapy and/or transdermal application of active substances.
Core Innovation
The invention relates to an electrically heatable, self-adhesive plaster for administering heat to the skin of a patient. The plaster includes a self-adhesive skin contact layer comprising at least one pharmaceutical active substance and an electrically conductive textile sheet that constitutes a rear layer of the plaster. The electrically conductive textile sheet comprises a fabric, a knitted structure, a crocheted structure, a braided structure, a bi-directional or multi-directional fabric, a felt, or a fleece of fibers, with a plurality of electrically conductive fibers in contact with one another.
A key aspect is that the electrically conductive textile sheet is provided with electrical contacts and forms a heating element by closing a circuit between a voltage source and the electrically conductive textile sheet. The flexible electrically conductive textile sheet enables an electrically heatable plaster arrangement intended to provide homogeneous heat distribution and controllable temperature management for hours. The electrically heatable plaster can include optional layers such as a substance-impermeable rear layer and a heat-insulating layer, as well as a removable protective layer.
The plaster is described for transdermal use as a transdermal therapeutic system for administering an active substance plaster to improve skin permeation. The described approach is associated with reducing the need for permeation enhancers, while still administering the pharmaceutical active substance. In vitro permeation testing is described using a modified diffusion cell and dermamoised human skin, with improved permeation for diclofenac when heated via the electrically heated rear layer compared with passive control at different temperatures.
Claims Coverage
The provided independent claims cover methods for administering heat to a patient’s skin and for administering at least one pharmaceutical active substance using an electrically heatable, self-adhesive plaster with an electrically conductive textile rear layer. Across the independent claims, the inventive requirements include conductive fibres in contact within a textile sheet, electrical contacts, a self-adhesive skin contact layer containing at least one pharmaceutical active substance, and the formation of an electrically heatable rear layer; at least one independent claim also explicitly recites closing a circuit between a voltage source and the conductive textile sheet.
Electrically heatable self-adhesive plaster with conductive textile rear layer and electrical contacts
Applying an electrically heatable plaster having a self-adhesive skin contact layer comprising at least one pharmaceutical active substance, and an electrically conductive, textile sheet constituting a rear layer, where a plurality of electrically conductive fibers are in contact with one another and the electrically conductive textile sheet is provided with electrical contacts.
Closing a circuit between voltage source and conductive textile sheet
Applying the electrically conductive textile sheet to a patient and closing a circuit between a voltage source and the electrically conductive textile sheet.
Direct current voltage source
The method is carried out using a direct current voltage source.
Electrically heatable plaster for administering at least one pharmaceutical active substance to a mammal
Providing an electrically conductive textile sheet with conductive fibers in contact and electrical contacts to provide an electrically heatable plaster having a self-adhesive skin contact layer comprising at least one pharmaceutical active substance, wherein the electrically conductive textile sheet constitutes the rear layer of the plaster, and including a step of applying the electrically heatable plaster to the skin of a mammal.
Administering pharmaceutical active substance contained in the heatable plaster to a patient
Providing an electrically heatable plaster having a self-adhesive skin contact layer comprising at least one pharmaceutical active substance, and an electrically conductive textile sheet with conductive fibers in contact provided with electrical contacts, wherein the electrically conductive textile sheet constitutes a rear layer of the plaster, and wherein the at least one pharmaceutical active substance contained in the plaster is administered to a patient.
Across the independent claims, the claim coverage centers on administering heat and/or at least one pharmaceutical active substance using a self-adhesive plaster that includes a conductive-fibre textile rear layer with electrical contacts, and on completing electrical heating by closing a circuit to the conductive textile sheet. One independent claim further specifies direct current, while other independent claims specify application to a mammal or administration of the active substance to a patient.
Stated Advantages
Homogeneous heat distribution.
Controllable temperature management for hours.
Improved skin permeation of the pharmaceutical active substance when the plaster is electrically heated.
Reducing the need for permeation enhancers.
Documented Applications
Transdermal therapeutic system use as an active substance plaster applied to skin to administer an active substance and improve skin permeation.
In vitro permeation testing on dermamoised human skin using a modified diffusion cell to evaluate permeation of diclofenac under electrical heating versus passive control.
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