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Publication Number
US-12329366-B2
Publication Date
2025-06-17
Expiration Date
Abstract
The present disclosure provides a medical procedure kit for ameliorating tissue damage in a patient, the kit comprising a container enclosing a receptacle, an extractor for extracting biological material including autologous cells from the patient, a strainer for straining autologous cells from the biological material and an implantable support having a surface onto which the autologous cells can adhere, the implantable support configured to be received by the receptacle. Also disclosed are related methods of manufacturing a medical material and using the medical procedure kit.
Core Innovation
The invention provides a hermetically sealable medical procedure kit for ameliorating tissue damage in a patient. The kit includes a container with an internal region that is hermetically sealed, and that internal region holds predefined storage locations together with a receptacle, a hollow needle, a cell strainer, and an implantable collagen membrane.
The hollow needle is for extracting bone marrow from the patient to obtain cells. The cell strainer comprises a mesh filter dimensioned to allow cells from the bone marrow to pass through while filtering out undesirable biological matter, thereby producing isolated cells. The implantable collagen membrane has a dimension smaller than the receptacle so that it is receivable in the receptacle, and it has a surface onto which the isolated cells can adhere.
The predefined storage locations are dimensioned to receive one or more of the implantable collagen membrane, hollow needle, or cell strainer, and are depressions integrally formed in a surface of an inner region of the container. The disclosed system is oriented toward an extraction-to-implantation workflow enabled by immediate or short-time preparation, and it distinguishes bone-marrow-like sources that do not require multi-day processing.
Claims Coverage
The independent claim defines a hermetically sealed medical procedure kit, with inventive features centered on a containerized assembly with predefined storage locations, a bone-marrow-extracting hollow needle, a mesh-based cell strainer for isolating cells while removing undesirable biological matter, and an implantable collagen membrane receivable in a receptacle for cell adhesion. The dependent claims further add a syringe, a conduit removably attachable between the hollow needle and a syringe, and refinements to the biological material basis and time constraint.
Hermetically sealed container with predefined storage locations
A container enclosing predefined storage locations integrally formed as depressions in an inner region, with the predefined storage locations dimensioned to receive one or more of the implantable collagen membrane, hollow needle or cell strainer, wherein the container is hermetically sealed to define an internal region in which the predefined storage locations, receptacle, hollow needle, cell strainer and implantable collagen membrane are located.
Bone marrow extracting hollow needle for isolating patient cells
A hollow needle for extracting bone marrow which contains cells from the patient, for use within the hermetically sealed internal region of the container.
Mesh cell strainer that filters out undesirable biological matter
A cell strainer comprising a mesh filter dimensioned to allow cells from the bone marrow to pass through and filter out undesirable biological matter from passing through the mesh filter to produce isolated cells, wherein the cell strainer has a dimension larger than the receptacle such that the cell strainer is positionable over the receptacle.
Implantable collagen membrane receivable in the receptacle for cell adhesion
An implantable collagen membrane having a dimension smaller than the receptacle such that the implantable collagen membrane is receivable in the receptacle, wherein the implantable collagen membrane has a surface onto which the isolated cells can adhere.
Syringe included in the containerized kit
The kit further includes a syringe as part of the container.
Conduit between hollow needle and syringe removably attachable
A hollow needle with a conduit removably attachable between the hollow needle and a syringe.
Biological material refined by structural/state characteristics
The hollow needle is used to extract bone marrow that either lacks a particular organised structure or is in an in-vivo fluid or gelatinous state.
Across the independent claim and its refinements, the invention centers on a hermetically sealed containerized kit that holds a receptacle, a bone-marrow-extracting hollow needle, a mesh-based cell strainer that isolates cells while filtering out undesirable biological matter, and an implantable collagen membrane sized for receival in the receptacle so that isolated cells can adhere.
Stated Advantages
Enables amelioration of tissue damage in a patient using the disclosed kit.
Provides a hermetically sealed internal region containing the receptacle, hollow needle, cell strainer, and implantable collagen membrane in predefined storage locations.
Produces isolated cells by filtering out undesirable biological matter using the mesh filter.
Enables isolated cells to adhere to the implantable collagen membrane via the membrane surface.
Supports immediate or short-time preparation oriented toward extraction-to-implantation and distinguishing sources that do not require multi-day processing.
Documented Applications
Ameliorating tissue damage in a patient, with a described example context including torn anterior cruciate ligament (ACL).
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