Device and method for real-time closed-loop brain stimulation
Inventors
Cohen, Roie • Zibman, Samuel • Zangen, Abraham • Roth, Yiftach
Assignees
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Publication Number
US-12318623-B2
Publication Date
2025-06-03
Expiration Date
Abstract
Brain stimulation techniques are disclosed, utilizing a brain state monitoring and stimulating component having at least one processor and memory, and a digital signal processing unit configured and operable to predict at least one brain state about to occur in a brain of a treated subject based on data or signals indicative of at least one brain state of the treated subject. The digital signal processing unit can be configured to generate based on the predicted at least one brain state stimulation data for adjusting, regulating or triggering, brain stimulation signals applied to the brain of the treated subject. The at least one processor, memory, and digital signal processing unit are embedded in some embodiments in a single hardware device.
Core Innovation
The disclosed invention provides a brain stimulation system for application of non-invasive electric, magnetic, and/or electromagnetic brain stimulation signals to a treated subject. The system includes sensing means for acquiring brain state signals from the treated subject and an integrated circuit device with at least one processor, at least one memory, and a digital signal processing (DSP) unit. The DSP unit processes the acquired brain state signals and removes artifacts and/or interferences induced by the non-invasive electric, magnetic, and/or electromagnetic brain stimulation signals applied by the system.
The integrated circuit is configured to predict at least one brain state about to occur in the treated subject. Based on the predicted brain state, the system generates brain stimulation data. A stimulation generator electrically connected to the integrated circuit device receives the brain stimulation data and generates the non-invasive electric, magnetic, and/or electromagnetic brain stimulation signals to be applied to the treated subject.
The stimulation generator uses the generated brain stimulation data to adjust and/or regulate, in real-time, at least one of shape, timing, and/or frequency of the non-invasive electric, magnetic, and/or electromagnetic brain stimulation signals applied to the treated subject. The at least one DSP unit comprises at least one prediction module configured to predict the at least one brain state about to occur based on previously acquired brain state signals.
Claims Coverage
The partial content includes two independent claims covering: (i) a complete brain stimulation system with sensing, DSP-based artifact removal, brain-state prediction, stimulation-data generation, and real-time adjustment of stimulation signal shape, timing, and frequency; and (ii) a corresponding integrated circuit that implements the same processing pipeline, including prediction based on previously acquired brain state signals, for real-time stimulation regulation.
Integrated circuit for artifact removal and brain-state prediction
An integrated circuit device comprising at least one processor, at least one memory, and a digital signal processing (DSP) unit configured to process acquired brain state signals and remove artifacts and/or interferences induced by the non-invasive electric, magnetic, and/or electromagnetic brain stimulation signals applied by the brain stimulation system; predict at least one brain state about to occur in the treated subject; and generate brain stimulation data.
Real-time stimulation adjustment by stimulation generator using generated data
A stimulation generator electrically connected to the integrated circuit device to receive the brain stimulation data from the DSP unit and generate the non-invasive electric, magnetic, and/or electromagnetic brain stimulation signals to be applied to the treated subject, adjusting and/or regulating in real-time at least one of shape, timing, and/or frequency of the non-invasive electric, magnetic, and/or electromagnetic brain stimulation signals applied to the treated subject.
Prediction module based on previously acquired brain state signals within the DSP unit
An integrated circuit in which the at least one DSP unit comprises at least one prediction module configured to predict the at least one brain state about to occur in the brain of the treated subject based on previously acquired brain state signals.
Across the independent claim set, the core inventive approach is an integrated circuit/DSP pipeline that removes artifacts and/or interferences from acquired brain state signals, predicts a brain state about to occur, and generates brain stimulation data used by a stimulation generator to adjust and/or regulate stimulation signal shape, timing, and/or frequency in real time.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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