Vaporized medicants and methods of use
Inventors
Chong, Alexander ChinHak • Bartkowski, William P • Thompson, Marshall A
Assignees
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Publication Number
US-12311006-B2
Publication Date
2025-05-27
Expiration Date
Abstract
A method and formulation for delivering a medication in a vaporized state using low temperatures to vaporize the formulation. The formulation contains an inert non-reactive compound that lowers the heat of vaporization of the formulation, and an alkaloid. The formulation may optionally contain glycerin, alcohol, and/or water. Examples of inert non-reactive compounds that can sufficiently lower the heat of vaporization of the formulation include propylene glycol, vegetable glycerin and polysorbate. The formulation can be vaporized using a hand-held low temperature vaporizer or atomizer.
Core Innovation
The invention provides a method for delivering medicants through inhalation by acquiring a medicant solution suitable for vaporization and vaporizing the medicant solution to provide an effective serving of the medicant for inhalation. The medicant solution includes an alkaloid and an excipient formulation designed for vaporization at specified temperature ranges.
In one implementation, the excipient comprises propylene glycol and vegetable glycerin together with water and alcohol in stated concentration ranges, and the medicant solution is vaporized at approximately 90 degrees C. to approximately 385 degrees C. In another implementation, the excipient comprises an inert non-reactive compound in which the inert non-reactive compound is polysorbate, and the medicant solution is vaporized at approximately 90 degrees C. to approximately 120 degrees C. using a low temperature vaporizer.
A further implementation specifies an excipient in which the inert non-reactive compound is propylene glycol, and the medicant solution is vaporized at approximately 170 degrees C. to approximately 200 degrees C. These approaches emphasize providing an effective serving while vaporizing at the claimed temperature range using the specified excipient compositions.
Claims Coverage
The independent claims cover medicant delivery through inhalation by vaporizing a medicant solution that includes an alkaloid and a defined inert excipient composition, with vaporization performed within claimed temperature ranges. Across the independent claims, the inventive features are expressed as three variants: a multi-component excipient, an inert non-reactive polysorbate excipient with a low temperature vaporizer, and an excipient where the inert non-reactive compound is propylene glycol.
Inhalation delivery using propylene glycol/vegetable glycerin/water/alcohol excipient and 90–385°C vaporization
Acquiring a medicant solution suitable for vaporization, where the medicant solution comprises an excipient including propylene glycol, vegetable glycerin, water, and alcohol, and an alkaloid; and vaporizing the medicant solution at a temperature ranging from approximately 90 degrees C. to approximately 385 degrees C. such that an effective serving of the medicant solution is provided to a user for inhalation.
Low-temperature inhalation delivery using inert non-reactive polysorbate excipient at 90–120°C with low temperature vaporizer
Acquiring a liquid medicant solution suitable for vaporization, where the liquid medicant solution comprises an excipient comprising an inert non-reactive compound and an alkaloid; and vaporizing the liquid medicant solution at a temperature ranging from approximately 90 degrees C. to approximately 120 degrees C., wherein the inert non-reactive compound is polysorbate, and wherein the step of vaporizing the medicant solution comprises using a low temperature vaporizer.
Inhalation delivery using propylene glycol inert excipient and 170–200°C vaporization
Acquiring a liquid medicant solution suitable for vaporization, where the liquid medicant solution comprises an excipient comprising an inert non-reactive compound and an alkaloid; and vaporizing the liquid medicant solution at a temperature ranging from approximately 170 degrees C. to approximately 200 degrees C., wherein the inert non-reactive compound is propylene glycol.
Overall, the independent claims focus on inhalation medicant delivery by vaporizing a medicant solution containing an alkaloid, with the defining features being the excipient composition and the corresponding vaporization temperature ranges, and one claim further requiring a low temperature vaporizer.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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