Organ container with oxygenation option
Inventors
Muylder, Peter De • Kravitz, David • STEINMAN, Christopher P • Pettinato, David • THEUNIS, Bernard
Assignees
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Publication Number
US-12310356-B2
Publication Date
2025-05-27
Expiration Date
Abstract
An organ container, which is for storing an organ or tissue and is able to be inserted into an apparatus for at least one of perfusion and transport of the organ or tissue, includes a basin configured to hold the organ or tissue and a perfusate bath. The organ container also includes tubing that (i) is connectable to a source of oxygen, (ii) includes a plurality of holes by which the oxygen may exit the tubing, and (iii) is located within the basin so as to be submerged within the perfusate bath present during the perfusion or transport of the organ or tissue.
Core Innovation
The disclosure provides an organ container basin configured to hold the organ or tissue and a perfusate bath during perfusion or transport, with at least one internal lid configured to cover the basin. Oxygenation components are integrated into the basin so that an oxygen-delivery tubing arrangement is located within the basin and submerged within the perfusate bath present during the perfusion or transport. The container further includes a connector within the basin for connecting and disconnecting the tubing within the basin with an oxygen line that extends outside the basin.
An oxygen supply conveys oxygen from a source of oxygen to the tubing through an oxygen line, where a first end of the oxygen line is within the basin and a second end is outside the basin. The tubing includes a plurality of holes by which the oxygen may exit the tubing, with the holes arranged such that oxygen can be delivered as bubble oxygenation through submerged holes. The lid and venting relationships coordinate coverage so that the oxygen line is covered by a first external lid and a second external lid when the lids are closed, while the second end of the oxygen line is exposed when the first external lid is closed and the second external lid is open.
In addition to the submerged oxygen delivery, the disclosure describes an oxygenation option that can support switching between submerged bubble oxygenation and surface oxygenation, while maintaining the hypothermic environment with lid management. Optional features include a hydrophobic vent/porous hydrophobic membrane and an anti-bacterial filter at the oxygen line outlet. Quantified oxygenation parameters and tubing/hole geometry are described to saturate perfusate oxygenation within a stated time period.
Claims Coverage
Independent claim clm-00001 defines an apparatus-level organ perfusion/transport container with an internal submerged oxygen-delivery tubing and a basin connector that interfaces to an oxygen line extending outside the basin, together with coordinated internal and external lids to manage exposure and coverage of the oxygen line end. The claim set includes multiple dependent limitations that add specific connector/filter features and dimensional/arrangement constraints for the plurality of holes and/or oxygen-delivery tubing.
Organ container with basin and internal lid coverage
An organ container for storing the organ or tissue, comprising a basin configured to hold the organ or tissue and a perfusate bath, and at least one internal lid configured to cover the basin.
Submerged oxygen-delivery tubing within perfusate bath
Tubing connectable to a source of oxygen, including a plurality of holes by which the oxygen may exit the tubing, with the tubing located within the basin so as to be submerged within the perfusate bath present during the perfusion or transport of the organ or tissue.
Basin connector linking submerged tubing to external oxygen line
A connector within the basin configured to connect and disconnect the tubing within the basin with an oxygen line that extends outside the basin, where an oxygen line conveys oxygen from the source of oxygen to the tubing and has a first end within the basin and a second end outside the basin.
Coordinated first and second external lids for oxygen line coverage and exposure
A first external lid and a second external lid adjacent to but not covering the first external lid, where the first external lid covers the basin when closed, the second external lid does not cover the basin when closed but covers other components including the second end of the oxygen line, and where the oxygen line is covered by the first and second external lids when both are closed while the second end of the oxygen line is exposed when the first external lid is closed and the second external lid is open.
Antibacterial filter at oxygen line outlet
The apparatus further includes an anti-bacterial filter at the second end of the oxygen line.
Internal lid sits between first external lid and basin
The at least one internal lid sits between the first external lid and the basin when the first external lid is closed.
Basin connector connection using tubing and T-fitting
A connector is connected to tubing within the basin via another tubing and a T-fitting.
Connector as Luer Lock fitting
The connector is a Luer Lock fitting.
Groupings and hole geometry for oxygen exit holes
Pairs of the plurality of groupings are spaced apart by about 34.79 mm of the tubing and each hole has an average diameter between 0.10 mm and 0.18 mm.
Across the independent claim and its dependents, the core inventive coverage is directed to an organ/container apparatus for perfusion or transport with a basin and internal lid, submerged oxygen-delivery tubing having a plurality of oxygen-exit holes, a basin connector that connects/disconnects the submerged tubing to an oxygen line extending outside the basin, and coordinated external lids that govern coverage of the oxygen line versus exposure of its second end. Dependent claims further refine the connector/filter features and specify hole/tubing grouping geometry.
Stated Advantages
Documented Applications
No documented applications found
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