Analytic device
Inventors
DeJohn, Marc Dominic • vanWestrienen, Jesse Wilson • Maksutovic, Maximilian
Assignees
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Publication Number
US-12305230-B2
Publication Date
2025-05-20
Expiration Date
Abstract
An analytic device comprising a device housing, a dock to receive a camera enabled mobile electronic device, such as a smartphone and other smart devices, and a processing device to communicate with the mobile electronic device and to control a condition of the assay tube, such as temperature. In another example, the analytic device comprises a device housing and a circuit board. A processing device, a heating block defining a recess to support assay tube, and a resistive heater are surface mounted to the circuit board. A light source and a fan are also provided. A dock may be provided to support a mobile electronic device. The mobile electronic device communicates with the processing device to cause the application of reaction conditions to the assay tube, to perform a PCR procedure, for example. Methods are also disclosed.
Core Innovation
A portable analytic device for processing a sample includes a container comprising the sample, a holder configured to secure the container, and a heater configured to heat the sample in the container. The device also includes a mobile electronic device, and the heater has an opening configured for imaging of the processing.
A processor comprising a circuit is operatively coupled to the heater and is configured to receive one or more instructions from the mobile electronic device for processing the sample. In response to the one or more instructions, the processor uses the one or more instructions to direct the heater to heat the sample, and the heater opening provides imaging of the processing.
The portable analytic device is used to process sample workflows including nucleic acid amplification by performing a polymerase chain reaction. The mobile electronic device provides imaging of the processing and can comprise a CMOS sensor. The device architecture further includes features to perform temperature cycling by controlling heating and cooling under instruction received from the mobile electronic device.
Claims Coverage
The independent claim is directed to a portable analytic device that combines sample heating with instruction-driven control from a mobile electronic device and provides an imaging opening in the heater for imaging the processing. The claim coverage includes seven inventive features.
Instruction-driven heater control using a mobile electronic device
A processor configured to receive one or more instructions from the mobile electronic device for processing the sample, and in response use the one or more instructions to direct the heater to heat the sample.
Heater opening configured for imaging of the processing
A heater configured with an opening configured for imaging of the processing.
Bi-directional data exchange for instructions and results
A data exchange unit configured to communicate with the mobile electronic device to receive instructions and to send processing results for a sample back to the mobile device.
Thermal coupling between heater and holder via a heating block
A holder configured such that a heating block is thermally connected to the heater.
Temperature cycling using a cooling unit under processor control
A cooling unit coupled to the processor to perform temperature cycling of the sample in the container using the heating block and the cooling unit under control of instructions received from the mobile electronic device.
Nucleic acid amplification by polymerase chain reaction
A processing configuration that amplifies a nucleic acid molecule by performing a polymerase chain reaction (PCR) procedure.
Mobile electronic device comprising a CMOS sensor
The mobile electronic device of the device includes a CMOS sensor.
Across the provided independent claim and identified dependent refinements, the claim coverage centers on a portable analytic device in which a mobile electronic device provides processing instructions to a processor that directs a heater, while the heater includes an imaging opening to image the processing, with further coverage including data exchange, heater-holder thermal coupling, temperature cycling with cooling, PCR nucleic acid amplification, and a CMOS sensor for imaging.
Stated Advantages
Documented Applications
No documented applications found
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