Metal hydroxide complex comprising modified multilayer hydroxide structure comprising active ingredient and method of manufacturing same
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Publication Number
US-12297213-B2
Publication Date
2025-05-13
Expiration Date
Abstract
The present invention relates to a metal hydroxide complex including the multilayer hydroxide structure of Chemical Formula 1, including a base layer, a surface layer and an active ingredient, a metal hydroxide complex manufactured by subjecting an active ingredient and a metal hydroxide structure precursor to coprecipitation through a precipitation reaction using an alcohol and water, and a method of manufacturing the same.
Core Innovation
The invention relates to a metal hydroxide complex comprising a multilayer hydroxide structure of Chemical Formula I, where the multilayer hydroxide structure includes a base layer, a surface layer, and an active ingredient. The active ingredient is represented by A, where A is an anionic compound comprising ascorbic acid. The multilayer hydroxide structure is expressed in terms of divalent metal cations M, with specified compositional parameter ranges for x, y, z, w, z+w, q, mis, and n.
The multilayer hydroxide structure is characterized by a powder-X-ray diffraction pattern having peak values of diffraction angles (2θ) within specified sets of peak values. The base layer [Mx(OH)z]B and the surface layer [My(OH)w]S are defined within the Chemical Formula I framework, and the active ingredient (anionic compound comprising ascorbic acid) is incorporated into the multilayer hydroxide complex as {(An)q}·m(H2O).
The described problem is addressed by providing a cosmetic metal hydroxide complex having a modified multilayer hydroxide structure (base layer/surface layer) that enables higher active ingredient loading/excess and improved performance. The document further reports enhanced sustained release, improved stability/long-term storage, and reduced skin irritation, along with reduced processing time and reduced active-material deterioration during solvent and drying-related steps [procedural detail omitted for safety].
Claims Coverage
The independent claims are directed to a metal hydroxide complex defined by Chemical Formula I with base layer and surface layer and an anionic active ingredient comprising ascorbic acid, and to the complex being characterized by specific powder-X-ray diffraction peak values of 2θ. Across the independent claims, the coverage includes multiple sets of 2θ peak values and shared compositional parameter ranges for the Chemical Formula I multilayer hydroxide structure.
Chemical Formula I multilayer hydroxide complex with base and surface layers
A metal hydroxide complex comprising a multilayer hydroxide structure of Chemical Formula I, comprising a base layer, a surface layer and an active ingredient, where [Mx(OH)z]B represents the base layer and [My(OH)w]S represents the surface layer.
Anionic active ingredient comprising ascorbic acid in Chemical Formula I
The active ingredient is represented by A, in which A is an anionic compound comprising ascorbic acid, and the multilayer hydroxide complex includes {(An)q}·m(H2O) in the Chemical Formula I framework.
Specific divalent metal cation and compositional parameter ranges in Chemical Formula I
M is any one divalent metal cation selected from Zn2+, and x, y, z, w, z+w, q, mis, and n are constrained to the stated ranges within Chemical Formula I.
Powder-X-ray diffraction peak pattern (first specified 2θ set)
The multilayer hydroxide structure has a powder-X-ray diffraction pattern having peak values of diffraction angles (2θ) of 5.96±1°, 33.46±1°, and 59.3±1°.
Powder-X-ray diffraction peak pattern (second specified 2θ set)
The multilayer hydroxide structure has a powder-X-ray diffraction pattern having peak values of diffraction angles (2θ) including 5.96±1°, 8.5±1°, 10.36±1°, 13.36±1°, 19±1°, 20.84±1°, 21.7±1°, 26.34±1°, 37.68±1°, 31.48±1°, 33.78±1°, 34.88±1°, and 59.3±1°.
Powder-X-ray diffraction peak pattern (third specified 2θ set)
The multilayer hydroxide structure has a powder-X-ray diffraction pattern having peak values of diffraction angles (2θ) of 6.28±1°, 8.88±1°, 10.32±1°, 13.42±1°, 21.04±1°, 28.14±1°, 33.5±1°, and 59.16±1°.
Overall, the independent claims define a cosmetic metal hydroxide complex through a Chemical Formula I multilayer hydroxide structure with a base layer and surface layer, incorporating an anionic active ingredient comprising ascorbic acid, constrained by divalent metal cation selection and compositional ranges, and further limited by specified powder-X-ray diffraction 2θ peak sets.
Stated Advantages
Higher active ingredient loading/excess.
Enhanced sustained release.
Improved stability/long-term storage.
Reduced skin irritation.
Reduced processing time (reported about 3–5 hr versus about 10–12 hr).
Less active-material deterioration during solvent and drying steps [procedural detail omitted for safety].
Documented Applications
In-vitro collagen efficacy using human dermal fibroblasts, including increased COL1A1 and COL3A1 mRNA expression (with TGF-β as a positive control) and cell viability assessment (WST-1).
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