Eliminating acquisition-related artifacts in electrophysiological recording
Inventors
Melman, Ryan Orin • Gilmour, Justin James • VON BRASCH, Alex • Lupton, Todd
Assignees
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Publication Number
US-12295751-B2
Publication Date
2025-05-13
Expiration Date
Abstract
Aspects presented herein are directed to techniques for eliminating acquisition related artifacts in electro-physiological recording. In order to eliminate artifacts in neural response recordings, a pair of recordings is made with, respectively, inverted and non-inverted polarity at one pair of electrodes. An the average of the two recordings will eliminate the acquisition artifact without the need for an extra recording, such as a baseline.
Core Innovation
The invention relates to electrophysiological recording with an implantable medical device in which acquisition-related switch-on artifacts are reduced for in vivo signals evoked in response to electrical stimulation. A first electrical stimulus is applied to at least one stimulating electrode set to a first polarity, and a first trace is acquired using a set of recording electrodes connected to a positive input and a negative input corresponding to that first polarity.
The connections associated with the set of recording electrodes are then switched so that the first recording electrode is connected to the negative input and the second recording electrode is connected to the positive input, thereby changing the polarity of the recording electrodes from the first polarity to a second polarity inverted relative to the first polarity. A second electrical stimulus is applied while the stimulating electrode remains set to the first polarity, and a second trace is acquired during recording epochs in which the recording electrodes are set to the second polarity.
A signal with reduced acquisition artifact is obtained based on the first trace and the second trace, including cancellation of the acquisition artifact when taking differences between traces while keeping an internal differential-amplifier artifact unchanged across the polarity inversion. The approach is described as applicable to recordings such as NRT/ECAP/EECAP.
Claims Coverage
The partial document provides two independent claims, a method claim and a non-transitory computer readable media claim, each centered on reversing recording-electrode polarity between two stimulus and recording acquisitions and obtaining a reduced acquisition-artifact signal based on the two acquired traces. Across the independent claims, the core coverage focuses on polarity switching of recording electrodes while stimulating electrodes remain set to a first polarity, followed by combining the two traces to reduce acquisition artifact.
Polarity-reversed recording electrodes with reduced acquisition artifact
Applying at least a first electrical stimulus to at least one stimulating electrode of an implantable medical device while the at least one stimulating electrode is set to a first polarity; acquiring a first trace via a set of recording electrodes during probe epochs when the set of recording electrodes are set to the first polarity with the first recording electrode connected to a positive input and the second recording electrode connected to a negative input; switching connections of the set of recording electrodes to invert polarity so the first recording electrode is connected to the negative input and the second recording electrode is connected to the positive input; applying at least a second electrical stimulus while the at least one stimulating electrode is set to the first polarity; acquiring a second trace during epochs when the set of recording electrodes are set to the second polarity; obtaining a signal with a reduced acquisition artifact based on the first trace and the second trace.
Computer-executable instructions for reduced acquisition artifact using inverted recording polarity
Initiating delivery of a first set of electrical stimulation signals via a first one or more stimulating electrodes of an implantable medical device while the first one or more stimulating electrodes are set to a first polarity; acquiring a first trace via a set of recording electrodes connected so that a first recording electrode is connected to a positive input and a second recording electrode is connected to a negative input during time periods when the set of recording electrodes are set to the first polarity; switching connections associated with the set of recording electrodes so the first recording electrode is connected to the negative input and the second recording electrode is connected to the positive input to invert polarity; initiating delivery of a second set of electrical stimulation signals via a second one or more stimulating electrodes set to the first polarity; acquiring a second trace during time periods when the second one or more stimulating electrodes are set to the first polarity and the set of recording electrodes are set to the inverted second polarity; obtaining a signal with reduced acquisition artifact based on the first trace and the second trace.
Both independent claims broadly cover obtaining a reduced acquisition-artifact signal by acquiring two traces under opposite recording-electrode polarities, achieved by switching connections, while delivering electrical stimulation with stimulating electrodes set to a first polarity, then obtaining the reduced-artifact signal based on the first and second traces.
Stated Advantages
Reduced acquisition artifact by canceling acquisition-related switch-on artifacts when obtaining the signal based on the first trace and the second trace.
Reduced noise floor.
Reduced measurement time.
Documented Applications
Electrophysiological recording for implantable neural recording signals such as NRT/ECAP/EECAP, including in vivo signals evoked in response to electrical stimulation.
Use with evoked compound action potential (ECAP) and acoustic reflex threshold.
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