Apparatus and method for delivery of antimicrobial during a transdermal sampling and delivery process
Inventors
Paranjape, Makarand • Paranjape, Shruti M.
Assignees
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Publication Number
US-12295729-B2
Publication Date
2025-05-13
Expiration Date
Abstract
A device for introducing at least one antimicrobial in an exposed region of a user's skin caused while accessing interstitial fluid includes a substrate having thereon at least one electrically controllable microheating element including at least a microheater portion with multiple electrodes connected to the microheater portion for forming a micropore in the user's skin. A nanofiber mat loaded with at least one antimicrobial material is arranged on the substrate such that it contacts the user's skin and encircles an opening of the micropore formed by the microheating element. In a preferred embodiment, the at least one antimicrobial material is LL-37.
Core Innovation
The invention relates to a device for introducing at least one antimicrobial in an exposed region of a user's skin that is caused while accessing interstitial fluid of a user. The device includes a substrate having multiple individually controllable sites for accessing interstitial fluid, where each site includes an electrically controllable microheating element with a microheater portion and multiple electrodes connected to the microheater portion.
The microheating element is configured to cause a micropore in the user's skin by thermal ablation of at least a portion of the skin's stratum corneum. Each individually controllable site further includes a generally ring shaped nanofiber mat loaded with multiple antimicrobial materials including LL-37, disposed directly on at least a portion of the microheating element on a skin-facing side of the substrate.
The nanofiber mat has a ring width of 5 to 25 μm and is arranged to contact the user's skin and encircle an opening of the micropore, thereby coordinating antimicrobial presence with micropore formation. A related patch embodiment includes the same functional combination of multiple individually controllable micropore-forming sites for accessing interstitial fluid and monitoring at least one analyte, together with an adhesive configured to adhere the patch to the skin on the skin-facing side of the substrate.
Claims Coverage
The patent portion provides two independent claims. Across these claims, the main inventive features combine electrically controllable microheating for thermally ablating micropores in stratum corneum with a ring-shaped nanofiber mat loaded with multiple antimicrobial materials including LL-37 that contacts the skin and encircles the micropore opening, with a defined ring width and placement on the microheater on a skin-facing side of a substrate.
Electrically controllable microheating micropore formation with multiple electrodes
A mechanism configured to cause a micropore in the user's skin by thermal ablation of at least a portion of the skin's stratum corneum, where the mechanism includes at least one electrically controllable microheating element having at least a microheater portion with multiple electrodes connected to the microheater portion configured to cause the micropore.
Ring shaped nanofiber mat loaded with multiple antimicrobial materials including LL-37 encircling the micropore opening
A generally ring shaped nanofiber mat loaded with multiple antimicrobial materials including LL-37 having a ring width of 5 to 25 μm, disposed directly on at least a portion of the microheating element on a skin-facing side of the substrate and arranged such that it is configured to contact the user's skin and encircle an opening of the micropore.
Multiple individually controllable sites on a substrate for accessing interstitial fluid
A substrate having multiple individually controllable sites for accessing interstitial fluid of a user, where each of the multiple individually controllable sites includes the electrically controllable microheating element mechanism for micropore formation and the ring shaped nanofiber mat for contacting and encircling the micropore opening.
Patch with analyte monitoring and adhesive on a skin-facing side
A patch including multiple individually controllable sites for accessing interstitial fluid and monitoring at least one analyte therein, where the substrate includes the micropore-forming mechanism and the ring shaped nanofiber mat disposed directly on the microheating element on a skin-facing side, and further includes an adhesive configured to be disposed on the skin-facing side for adhering the patch to the skin of the user.
Overall, the claim coverage centers on the pairing of thermally ablated micropores in the stratum corneum using electrically controllable microheating elements with multiple electrodes, and a skin-contacting ring shaped nanofiber mat loaded with multiple antimicrobial materials including LL-37 that encircles the micropore opening with a defined ring width and placement directly on the microheater on the skin-facing side. In the patch claim, these features are combined with monitoring at least one analyte and an adhesive to adhere the patch to skin.
Stated Advantages
Documented Applications
No documented applications found
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