Control of sample separation based on analysis of mobile phase supply from mobile phase container
Inventors
Schuhn, Bettina • Effelsberg, Uwe • van Venrooy, Manuel • Kamuf, Matthias
Assignees
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Publication Number
US-12292420-B2
Publication Date
2025-05-06
Expiration Date
Abstract
A method of controlling a sample separation apparatus, for separating a fluidic sample using a mobile phase provided from at least one mobile phase container, includes determining a weight and volume reduction behavior according to which weight and volume of mobile phase in a mobile phase container are reduced during conveying mobile phase from the mobile phase container in the sample separation apparatus, and determining a tare weight of the mobile phase container based on a gross weight information, a volume information, and the determined weight and volume reduction behavior. The gross weight information is indicative of an initial gross weight of the mobile phase container including its mobile phase, and the volume information is indicative of an initial mobile phase volume in the mobile phase container.
Core Innovation
The invention provides a method for controlling a sample separation apparatus that separates a fluidic sample using a mobile phase provided from at least one mobile phase container. The method determines a weight and volume reduction behavior according to which weight and volume of mobile phase in the mobile phase container are reduced during conveying mobile phase from the mobile phase container in the sample separation apparatus, and determines a tare weight of the mobile phase container based on gross weight information, volume information, and the determined weight and volume reduction behavior.
The gross weight information is indicative of an initial gross weight of the mobile phase container including mobile phase contained in the mobile phase container, and the volume information is indicative of an initial mobile phase volume in the mobile phase container. Using these inputs together with the weight and volume reduction behavior allows determination of the container tare weight while the mobile phase is conveyed and reduced during operation of the sample separation apparatus.
The approach also supports predicting whether remaining mobile phase is sufficient for a predefined separation run and enables conditional actions based on that prediction. The document further describes determining or estimating additional properties such as density of the mobile phase from the weight and volume reduction behavior and comparing actual container-measured conveyance with conveyance derived from operation parameters to detect discrepancies and support qualification-style compliance.
Claims Coverage
The partial content provides two independent claims. Across these, the central inventive set is determining a weight and volume reduction behavior during conveying and using gross weight information and volume information together with that reduction behavior to determine a tare weight for the mobile phase container.
Tare weight determination from reduction behavior
Determining a weight and volume reduction behavior according to which weight and volume of mobile phase in a mobile phase container are reduced during conveying mobile phase from the mobile phase container in the sample separation apparatus; and determining a tare weight of the mobile phase container based on gross weight information, volume information, and the determined weight and volume reduction behavior, wherein the gross weight information is indicative of an initial gross weight of the mobile phase container including mobile phase and the volume information is indicative of an initial mobile phase volume in the mobile phase container.
Reduction behavior determining and tare weight determining units
An input unit for inputting gross weight information indicative of an initial gross weight of a mobile phase container including its mobile phase and volume information indicative of an initial mobile phase volume; a reduction behavior determining unit for determining a weight and volume reduction behavior according to which weight and volume of mobile phase in the mobile phase container are reduced during conveying mobile phase from the mobile phase container in the sample separation apparatus; and a tare weight determining unit for determining a tare weight of the mobile phase container based on the gross weight information, the volume information, and the determined weight and volume reduction behavior.
Both independent claims center on determining weight and volume reduction behavior during conveying mobile phase and then using that determined reduction behavior together with initial gross weight information and initial mobile phase volume to determine the tare weight of the mobile phase container.
Stated Advantages
Allows determination of tare weight of the mobile phase container based on gross weight information, volume information, and weight and volume reduction behavior.
Supports prediction of whether mobile phase is sufficient for a predefined separation run and conditional actions based on that prediction.
Enables determining the density of the mobile phase based on the determined weight and volume reduction behavior.
Enables comparison between actual container-measured conveyance and conveyance derived from operation parameters to detect discrepancies.
Documented Applications
Controlling a sample separation apparatus for separating a fluidic sample using a mobile phase provided from at least one mobile phase container.
Using the control device and method within a sample separation apparatus that can include chromatography configuration, a detector, and fraction collection, with an injector that injects the fluidic sample in a mobile phase.
Supporting predefined separation run execution decisions, including warning, stopping, or disabling until sufficient mobile phase is provided.
Supporting qualification-style specification compliance using IQ/OQ/PQ-style actions as described in the document.
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