Method and system to monitor urine output and manage fluid retention in a patient
Inventors
Levin, Howard • Halpert, Andrew • Gelfand, Mark
Assignees
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Publication Number
US-12290380-B1
Publication Date
2025-05-06
Expiration Date
Abstract
A method to treat patients suffering from fluid overload including: administrating a diuretic to the patient to increase urine output of the patient; monitoring intravascular volume of the patient; and maintaining the patient in a condition in which the intravascular volume is below a baseline intravascular volume and above a hemodynamic level by adjusting the administered diuretic.
Core Innovation
The invention relates to a method to reduce liquid levels of a patient by monitoring urine output and infusing a hydration liquid configured to prevent or treat dehydration. A net rate of liquid removal from the patient is determined based on a difference between the urine output and the infusion of the hydration liquid.
The method obtains a first intravascular volume level corresponding to a baseline intravascular volume level, and obtains a second intravascular volume level corresponding to an at risk intravascular volume level. During a first period, the method causes infusion of the hydration liquid at a first hydration rate greater than the rate of urine output to reduce an intravascular fluid volume of the patient.
During a second period after the rate of urine output reaches or exceeds a predetermined urine output threshold, the method adjusts the infusion of the hydration liquid to a second hydration rate that is different than the first hydration rate and less than the rate of the urine output. The method maintains the intravascular fluid volume of the patient during the second period between the first intravascular volume level and the second intravascular volume level.
The at risk intravascular volume level is associated with a hemodynamic fluid level below which there is risk of vital organ damage, and the control can include hydration infusion to keep net fluid removal within a fluid-loss-limit using urine output as feedback.
Claims Coverage
The provided material includes one independent claim. Across that independent claim and its dependent claims, there are three main inventive feature themes: urine-output-based net liquid removal determination with hydration co-infusion, two-period hydration rate control tied to a urine output threshold, and maintaining intravascular volume between baseline and at-risk levels, with dependent refinements adding rate constraints and defining the hemodynamic basis of the at-risk level.
Urine output monitoring with hydration infusion and net rate determination
Monitoring urine output by the patient, infusing a hydration liquid configured to prevent or treat dehydration into the patient, and determining a net rate of liquid removal from the patient based on a difference between the urine output and the infusion of the hydration liquid.
Two-period hydration-rate control to reduce intravascular volume then hold volume between baseline and at-risk
Obtaining a first intravascular volume level corresponding to a baseline intravascular volume level and obtaining a second intravascular volume level corresponding to an at risk intravascular volume level; during a first period causing infusion of the hydration liquid at a first hydration rate greater than a rate of the urine output to reduce an intravascular fluid volume of the patient; and during a second period after the rate of the urine output reaches or exceeds a predetermined urine output threshold, adjusting the infusion of the hydration liquid to a second hydration rate different from the first hydration rate and less than the rate of the urine output, wherein during the second period the intravascular fluid volume remains between the first and second intravascular volume levels.
At-risk intravascular volume level defined by risk of vital organ damage
Configuring the at risk intravascular volume level to correspond to a hemodynamic fluid level below which there is risk of vital organ damage.
The claim coverage centers on an intravascular-volume-targeted dewatering approach that uses urine output to determine net liquid removal while switching hydration infusion rates across two periods, and maintaining intravascular volume between a baseline level and an at-risk level associated with vital organ damage risk.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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