Centrifugal fluid separation device
Inventors
Ladtkow, James R. • Hlavinka, Dennis J. • Felt, Thomas J. • Gloor, Andrew • Janzen, Jesse • Polodna, Taylor • Storm, Luke Edwin
Assignees
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Publication Number
US-12285757-B2
Publication Date
2025-04-29
Expiration Date
Abstract
A modular cassette is provided for separating a composite fluid into at least two component parts thereof during centrifugation. The modular cassette includes: a housing defining a fluid inlet, a fluid outlet, and a chamber for fluid separation; a fluidic channel configured to provide fluid communication between at least two components of the modular cassette; a heat expanding valve including: a flow pathway including undulations configured to facilitate closing of the fluidic channel, wherein the heat expanding valve occludes one or more of the undulations of the flow pathway to close the fluidic channel; and a heating element configured to actuate the heat expanding valve.
Core Innovation
The invention relates to a modular cassette for separating a composite fluid into at least two component parts during centrifugation. The cassette includes a housing defining a fluid inlet, a fluid outlet, and a chamber for fluid separation, and it includes a fluidic channel configured to provide fluid communication between at least two components of the modular cassette.
A heat expanding valve is provided to facilitate closing of the fluidic channel. The heat expanding valve includes a flow pathway with undulations configured to facilitate closing of the fluidic channel, and the heat expanding valve occludes one or more of the undulations of the flow pathway to close the fluidic channel.
A heating element is configured to actuate the heat expanding valve. The modular cassette is used as part of a rotor assembly for composite fluid separation during centrifugation, and the described modular architecture includes fluidic channels providing communication between cassette regions for aseptic disposable operation while enabling component separation from composite fluids including whole blood.
Claims Coverage
The independent claims cover a modular cassette that separates a composite fluid into at least two component parts during centrifugation using a housing/chamber arrangement, a fluidic channel for communication between cassette components, and a heat expanding valve that occludes undulations in a flow pathway to close the channel. Three inventive features are present across the independent claim language.
Modular cassette with separation chamber and communication fluidic channel
A modular cassette comprising a housing defining a fluid inlet, a fluid outlet, and a chamber for fluid separation; and a fluidic channel configured to provide fluid communication between at least two components of the modular cassette.
Heat expanding valve occluding undulations to close a fluidic channel
A heat expanding valve including a flow pathway including undulations configured to facilitate closing of the fluidic channel, wherein the heat expanding valve occludes one or more of the undulations of the flow pathway to close the fluidic channel.
Heating element actuating heat expanding valve
A heating element configured to actuate the heat expanding valve.
The core coverage combines a modular cassette with a fluid separation chamber and communication channel with a heat expanding valve and heating element for closing the channel by occluding undulations in the flow pathway.
Stated Advantages
PBMC recovery is described.
Yield improvement versus traditional workflows is described.
Aseptic disposable operation is described.
Pumpless G-field-driven fluid handling is described.
Documented Applications
Splitting a composite fluid, including whole blood, into component parts during centrifugation.
Recovery of PBMC from composite fluid during centrifugation.
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