Near-IR glucose sensors
Inventors
Gamsey, Soya • BERNAT, Viachaslau • KUTYAVIN, Alex • CLARY, Jacob William • PRADHAN, Sulolit
Assignees
Publication Number
US-12285250-B2
Publication Date
2025-04-29
Expiration Date
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Abstract
Glucose-sensing luminescent dyes of formula (IV-I), polymers, and sensors are provided. Additionally, systems including the sensors and methods of using these sensors and systems are provided.
Core Innovation
Glucose-sensing luminescent dyes of formula (IV-I), polymers, and sensors are provided. Additionally, systems including the sensors and methods of using these sensors and systems are provided. The disclosure describes luminescent dyes, polymers including said dyes, and sensors including the polymers, and identifies compounds and compositions of Formulae I-IIIH, AI, AIA, AIB, AIC, AII, AIIA, AIIB, AIII and compounds of Formula IV-I (and related subforms) as embodiments.
Diagnosis, treatment, and management of diabetes require monitoring of glucose concentration in the blood, and the background identifies that currently used methods are expensive, cumbersome, time consuming, and do not provide accurate, real-time blood glucose concentration information. The disclosure addresses a need for a better long-term, minimally invasive glucose-monitoring system that is Near IR-detectable in vivo and suitable for long-term implantation, noting limitations of present dyes and sensors including excitation wavelengths absorbed by skin and rigid sensor materials that induce a fibrous capsule response.
Claims Coverage
Two independent claims are identified. The main inventive features claimed are compounds defined by specific structural formulae and selections of specific compounds.
Compound of formula (IV-IA)
A compound of formula (IV-IA) as recited in the claim.
Compound selected from specified structures
A compound selected from the structures listed in the claim (the claim states 'A compound selected from:' followed by enumerated structures).
The independent claims define novel chemical compounds: one claim covers a compound of formula (IV-IA) and the other covers compounds selected from enumerated structures; dependent claims further describe polymers, sensors comprising residues of those compounds, and methods of measuring blood glucose using sensors based on those compounds.
Stated Advantages
Excitation and emission wavelengths in the optical window of the skin (approximately 550 nm to 1100 nm) allowing detection of analytes deep within a tissue or an organ.
High signal-to-noise ratio.
Large Stokes shifts and emission.
Photostability; the dyes and/or polymers do not undergo rapid photobleaching.
Sensors generate stable signal over long periods of time (examples listed: greater than a week, greater than 10 days, greater than 15 days, greater than 20 days, greater than a month, greater than 2 months, greater than 3 months, or greater than 6 months).
Tissue-integration of sensors enabling capillary in-growth and long-term detection.
Implantation through syringe injection or trocar injection so that no surgery is required to place the sensing media.
Sensors that do not include sensor electronics in the body.
Accurate assessment of analyte (e.g., glucose) concentration for long periods of time (greater than a week, weeks, months, or years).
Small device dimensions resulting in increased patient comfort and better acceptance by the body.
Documented Applications
In vivo and in vitro detection of analytes (for example, glucose) using luminescent sensors and polymers including covalently attached dye residues.
Long-term, continuous or semi-continuous implanted glucose monitoring in tissue, including subcutaneous implantation detectable transcutaneously.
Sensors in forms such as powder, fabric (e.g., bandage), needle, rod, disk, or other suitable forms.
Tissue-integrating scaffolds that promote capillary and tissue in-growth to enable long-term analyte sensing.
Multi-analyte sensing including, as explicitly listed, oxygen, reactive oxygen species, glucose, lactate, pyruvate, cortisol, creatinine, urea, sodium, magnesium, calcium, potassium, vasopressin, hormones, pH, cytokines, chemokines, eicosanoids, insulin, leptins, small molecule drugs, ethanol, myoglobin, nucleic acids, fragments, polypeptides, and single amino acids.
Use of NIR dye moieties and luminescent hydrogels for sensing and imaging applications with absorption and emission properties in the NIR optical window of skin.
Implantable glucose sensors that produce a detectable luminescent signal when placed up to about 5 mm deep under the skin of a mammalian subject.
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