Cooled mechanical circulatory support system and method of operation
Inventors
Josephy, Noam • Curran, Jerald
Assignees
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Publication Number
US-12280250-B2
Publication Date
2025-04-22
Expiration Date
Abstract
A mechanical circulatory support system for a heart having a cooling element and a method for using the system to treat the effects of a cardiac episode. The support system has a pump comprising a rotor, the rotor having at least one blade. The system also has a catheter having an inner surface and an outer surface, the catheter extending proximally of relative to the pump housing. The outer surface of the catheter is configured to contact blood when disposed within patient vasculature. The outer surface of the catheter comprises a heat transfer surface configured for cooling blood that comes in contact with the outer surface. The support system is operated to provide a temperature selected to cool the circulating blood in contact with the outer surface of the catheter to a temperature selected to reduce or prevent an effect of a cardiac episode.
Core Innovation
The invention relates to a mechanical circulatory support system for a heart that unloads the heart while simultaneously cooling a patient using controlled hypothermia associated with a cardiac episode. The system is configured to treat or limit cardiac-episode effects, including myocardial infarction scarring, and to manage risks associated with systemic hypothermia, including arrhythmias.
The mechanical circulatory support system includes a pump having a distal end and a proximal end, where the pump comprises a rotor with at least one blade and a pump housing surrounding the blade. A catheter extends proximally relative to the pump housing and has a distal end, a proximal end, an inner surface, and an outer surface configured to contact blood when disposed within patient vasculature.
A cooling element is configured to cool blood that comes in contact with the outer surface of the catheter, where the cooling element is formed as a lumen configured to receive a chilled solution. The described approaches also include thermoelectric cooling using a Peltier device having semiconductor junctions, as well as lumen geometries and reversible flow, including single helix and double helix configurations and configurations with configurable inlet and outlet functions.
Claims Coverage
The independent claim describes one mechanical circulatory support system architecture with a pump/rotor and a proximal catheter carrying a cooled interface to blood. The inventive portion centers on cooling a catheter-contact blood region by using a cooling element formed as a lumen that receives a chilled solution.
Mechanical circulatory support system with rotor-blade pump and proximal catheter cooled by chilled-solution lumen
A mechanical circulatory support system for a heart comprising a pump with a distal end and a proximal end, where the pump comprises a rotor having at least one blade and a pump housing surrounding the at least one blade; a catheter having a distal end, a proximal end, an inner surface, and an outer surface, the catheter extending proximally relative to the pump housing, the outer surface configured to contact blood within patient vasculature; and a cooling element configured to cool the blood that comes in contact with the outer surface of the catheter, wherein the cooling element is formed as a lumen configured to receive a chilled solution.
Across the inventive features, the claimed system cools blood contacting a catheter surface within a mechanical circulatory support, using a cooling element that is formed as a chilled-solution lumen. Dependent refinements further specify cooling location on the catheter, lumen inlet/outlet openings and opposite-direction flow portions, numeric constraints on systemic temperature, and a specific chilled crystalloid fluid.
Stated Advantages
Unload the heart while simultaneously inducing controlled hypothermia associated with a cardiac episode.
Treat or limit cardiac-episode effects, including myocardial infarction scarring.
Reduce arrhythmia risk associated with systemic hypothermia by performing cooling while the pump is actuated.
Documented Applications
Treatment or limiting of cardiac-episode effects, including myocardial infarction scarring, using a mechanical circulatory support system with controlled hypothermia.
Risk management for arrhythmias associated with systemic hypothermia by performing cooling while the pump is actuated.
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