Systems and methods for injection and aspiration
Inventors
CULBERT, BRADLEY S. • CARLSON, GARY D
Assignees
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Publication Number
US-12280222-B2
Publication Date
2025-04-22
Expiration Date
Abstract
A system for catheter-based aspiration includes an aspiration catheter having a distal portion configured for insertion within a blood vessel of a subject, the aspiration catheter including an aspiration lumen having a distal opening at the distal portion of the aspiration catheter, an injection lumen having a distal end at the distal portion of the aspiration catheter, and an orifice located at or near the distal end of the injection lumen, the orifice configured to direct liquid into the aspiration lumen at or near the distal opening of the aspiration lumen; an injector configured to pressurize the liquid within the injection lumen, such that liquid exits the orifice and enters the aspiration lumen; and a mechanical oscillator coupled to the injector and configured to cause a pulsatile pressure of the liquid as it is injected through the injection lumen.
Core Innovation
A catheter-based aspiration system is disclosed for insertion within a blood vessel of a subject. The aspiration catheter has an aspiration lumen with a distal opening and an injection lumen with a distal end, and an orifice located at or near the distal end of the injection lumen directs liquid into the aspiration lumen at or near the distal opening.
An injector pressurizes the liquid in the injection lumen so that liquid exits the orifice and enters the aspiration lumen. The system further includes a mechanical oscillator coupled to the injector, configured to cause pulsatile pressure of the liquid as it is injected through the injection lumen.
The injector comprises a barrel and a plunger, with the plunger sealingly displaceable within an interior of the barrel along a longitudinal displacement axis. The mechanical oscillator comprises a first disk and a second disk axially arrayed with respect to each other, where changes based upon relative rotational orientation between the first disk and the second disk cause reciprocal relative axial displacement between the first disk and the second disk, and the first disk transfers motive force to the plunger along the longitudinal displacement axis.
Claims Coverage
The independent claim identified is clm-00001. It includes four inventive features centered on a catheter lumen/orifice arrangement combined with an injector driven by a mechanical oscillator to generate pulsatile injection pressure.
Catheter lumen and distal orifice directing injection into aspiration
An aspiration catheter configured for insertion within a blood vessel, including an aspiration lumen with a distal opening and an injection lumen with a distal end, and an orifice located at or near the distal end of the injection lumen configured to direct liquid into the aspiration lumen at or near the distal opening.
Injector pressurizing liquid through an injection lumen into an aspiration lumen
An injector configured to pressurize the liquid within the injection lumen such that liquid exits the orifice and enters the aspiration lumen.
Mechanical oscillator coupled to the injector to create pulsatile injection pressure
A mechanical oscillator coupled to the injector and configured to cause a pulsatile pressure of the liquid as it is injected through the injection lumen.
Mechanical oscillator disk-to-plunger motive force conversion for reciprocal axial displacement
An injector comprising a barrel and a plunger with the plunger sealingly displaceable along a longitudinal displacement axis, and a mechanical oscillator comprising a first disk and a second disk axially arrayed such that relative rotational orientation causes reciprocal relative axial displacement, with the first disk coupled to the plunger and configured to transfer motive force along the longitudinal displacement axis.
The claim scope combines a catheter with aspiration and injection lumens and a distal orifice that directs injection into the aspiration lumen, an injector that pressurizes and delivers liquid through the injection lumen, and a mechanical-oscillator mechanism using axially arrayed disks coupled to a plunger to generate pulsatile injection pressure.
Stated Advantages
Real-time aspiration monitoring with alerts based on pressure/negative pressure conditions.
Ability to generate pulsatile pressure during injection into the aspiration lumen.
Pressure-based safety control for aspiration using alternative pump configurations.
Multi-purpose use for infusion/aspiration, including drug delivery and controlled cooling.
Documented Applications
Catheter-based aspiration for removing thrombus in a subject.
Real-time aspiration monitoring to detect conditions such as clogging/stuck thrombus and differentiation between active thrombus aspiration and free-flow blood.
Forced or assisted aspiration using high-pressure infusate jets.
Drug delivery and controlled cooling using multi-purpose infusion/aspiration catheters.
Optional reinfusion workflows using alternative aspiration pumps with pressure-based safety control.
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