Compositions and methods for epidural administration of MCOPPB for pain relief
Inventors
Assignees
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Publication Number
US-12268679-B1
Publication Date
2025-04-08
Expiration Date
Abstract
The invention provides compositions and methods for epidural administration of the compound MCOPPB or a pharmaceutically acceptable salt thereof for treating pain, such as nociceptive pain suffered by an adult human.
Core Innovation
The patent describes epidurally administering MCOPPB or a pharmaceutically acceptable salt thereof in a pharmaceutical composition that includes a pharmaceutically acceptable carrier, to treat pain in a patient in need thereof. The described purpose is to achieve long-duration pain relief with minimal inconvenience. Pain intensity is assessed using Visual Analogue Scale (VAS) measurements and is characterized relative to pain observed without administering the pharmaceutical composition.
The problem addressed is the need for a method of treating pain that provides substantial and sustained reduction in pain intensity for patients, including various pain types and pain syndromes. The description emphasizes quantitative thresholds and durations over which pain intensity is reduced, including thresholds such as at least about 20%, 40%, 60%, 80%, and 90% reduction compared to no treatment, and reduction durations ranging from hours up to weeks.
The patent further describes that the epidural administration is directed to treating pain including nociceptive, neuropathic, inflammatory, arthritic, cancer-related pain, complex regional pain syndrome, trauma and postoperative pain, and specified neuropathic pain subtypes. The described patient context includes adult humans, and the document also specifies pain locations and characterizes neuropathic pain selected from enumerated neuropathic pain types and combinations thereof.
Claims Coverage
The partial content provides two independent claims: one directed to a method of treating pain and one directed to a method of locally administering MCOPPB by epidural administration. Across the claims, there are two core inventive elements in the claim scope: epidural administration of a pharmaceutical composition including MCOPPB or a pharmaceutically acceptable salt thereof, and the presence of a pharmaceutically acceptable carrier within that composition.
Epidural administration of MCOPPB composition for treating pain
Epidurally administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition comprising MCOPPB or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier, to thereby treat the pain.
Epidural local administration of MCOPPB composition
Epidurally administering to a patient in need thereof a pharmaceutical composition comprising MCOPPB or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier, as a method of locally administering MCOPPB or a pharmaceutically acceptable salt thereof to a patient.
In the provided claim set, the inventive coverage centers on using epidural administration of a MCOPPB or pharmaceutically acceptable salt pharmaceutical composition that includes a pharmaceutically acceptable carrier. The treatment claim further requires a therapeutically effective amount to thereby treat pain, and the local administration claim focuses on local administration by epidural delivery of the same composition.
Stated Advantages
Long-duration pain relief with minimal inconvenience.
Documented Applications
Treating pain in adult human patients, including nociceptive, neuropathic, inflammatory, arthritic, cancer-related pain, complex regional pain syndrome, trauma and postoperative pain.
Treating cancer-selected pain for cancers selected from solid tumor, leukemia, or lymphoma.
Treating neuropathic pain selected from enumerated neuropathic pain types and combinations thereof.
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