Radiation mitigator and method of use thereof

Inventors

Brown, Milton L. • Kong, Yali • Houchen, Courtney • Sureban, Sripathi M. • CHANDRAKESAN, Parthasarathy

Assignees

Georgetown University • University of Oklahoma

Abstract

Provided are methods useful for preventing and mitigating radiation injury, including acute radiation syndrome, comprising administering to a subject a therapeutically effective amount of a compound represented by formula I or a pharmaceutically acceptable salt thereof, wherein Z is —O— or —N(H)—.

Core Innovation

The invention relates to methods for preventing or mitigating radiation-induced tissue injury and acute radiation syndrome by administering therapeutically effective amounts of compounds represented by formulas I and II, including pharmaceutically acceptable salts. The compounds are administered to a subject in need thereof, including mammal and human subjects, with treatment intended to treat or prevent the radiation-induced tissue injury in the subject.

The document defines radiation-induced tissue injury and describes target tissues including gastrointestinal tissue, hematopoietic tissue, neural tissue, and other organs. It describes methods in which a therapeutically effective amount of a compound represented by formula II, or a pharmaceutically acceptable salt thereof, is administered by routes including oral and parenteral administration.

The document states that the methods are applicable to situations involving ionizing radiation exposure, including nuclear disaster, accidental exposure, and aviation/spaceflight, as well as military personnel. It describes the therapeutic concept as acting to prevent or treat radiation-induced tissue injury and acute radiation syndrome across the specified tissues, with examples reporting improved tissue outcomes and survival outcomes following gamma irradiation and total body irradiation models.

Claims Coverage

The independent claim is directed to a method for treating or preventing radiation-induced tissue injury using a therapeutically effective amount of a compound represented by formula II (or a pharmaceutically acceptable salt). The claim coverage includes multiple inventive limitations around administration timing, administration route, and target tissue types.

Overall, the claim set covers treating or preventing radiation-induced tissue injury using therapeutically effective administration of a formula II compound (or a pharmaceutically acceptable salt), including limitations on timing (before or after exposure), route (parenteral), and target tissue (gastrointestinal), as well as explicitly covering prevention of the radiation-induced injury.

Stated Advantages

Documented Applications