Organ transport container with antiviral therapy
Inventors
Judson, Jared Alden • Anderson, Lisa Maria
Assignees
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Publication Number
US-12245585-B2
Publication Date
2025-03-11
Expiration Date
Abstract
A system for the hypothermic transport of biological samples, such as tissues, organs, or body fluids. The system includes an antimicrobial treatment mechanism to inactivate microbes flushed from the biological sample by preservation fluid flowed therethrough. The self-purging preservation apparatus is placed in an insulated transport container having a cooling medium. When assembled, the system allows for transport of biological samples for extended periods of time at a stable temperature while simultaneously treating microbial infections to prevent transmission between a donor and a recipient.
Core Innovation
The invention relates to a canister for transporting a biological sample under sterile conditions while maintaining perfusion using a circuit. The canister includes a sample storage chamber with a removable lid that couples with the chamber walls to form a sterile environment, and an adapter that supports the biological sample within the sterile environment so that the biological sample does not contact the chamber floor and walls.
The canister further includes a plurality of cooling blocks positioned around an exterior of the canister and a pumping mechanism operable to flow a perfusate in a circuit through the adapter to perfuse the biological sample. An antimicrobial treatment mechanism is disposed within the circuit to inactivate microbes flushed from the biological sample by the perfusate, and the antimicrobial treatment mechanism comprises a radiation source disposed within the removable lid.
The removable lid includes an opaque surface configured to optically isolate the radiation source from the biological sample. In the described embodiment, the radiation source provides optical irradiation for inactivation of microbes/viruses in flushed perfusate, including ultraviolet C in the range of about 250 nm to about 270 nm, or photodynamic therapy where a light-activated antimicrobial agent is activated by radiation from the radiation source.
Claims Coverage
Independent claim coverage focuses on transporting a biological sample in a sterile, sealed canister with perfusion via a circuit, cooling via exterior cooling blocks, and an antimicrobial treatment mechanism using a radiation source in the removable lid with optical isolation by an opaque lid surface. One independent claim is explicitly provided in the partial content.
Sterile sample chamber with removable lid forming sterile environment
A sample storage chamber comprising a floor and walls configured to receive a biological sample, and a removable lid operable to couple with the walls to form a sterile environment within the sample storage chamber.
Adapter supports sample without contacting floor and walls
An adapter configured to couple to and support the biological sample within the sterile environment without the biological sample contacting the floor and the walls.
Exterior cooling blocks and perfusate pumping circuit
A plurality of cooling blocks positioned around an exterior of the canister, and a pumping mechanism operable to flow a perfusate in a circuit through the adapter to perfuse the biological sample.
In-circuit antimicrobial treatment using a radiation source in removable lid
An antimicrobial treatment mechanism disposed within the circuit, the antimicrobial treatment mechanism comprising a radiation source in the removable lid operable to inactivate microbes flushed from the biological sample by the perfusate.
Opaque removable lid optically isolates radiation source from sample
The removable lid comprises an opaque surface configured to optically isolate the radiation source from the biological sample.
Across the provided independent claim, inventive coverage centers on combining a sterile canister structure with a removable lid and sample-supporting adapter, exterior cooling blocks and perfusion via a perfusate circuit, and an in-circuit antimicrobial mechanism where a radiation source located in the removable lid inactivates flushed microbes while an opaque surface optically isolates the radiation source from the biological sample.
Stated Advantages
Enables inactivation of microbes flushed from the biological sample by the perfusate using a radiation source disposed in the removable lid.
Provides optical isolation of the radiation source from the biological sample via an opaque surface of the removable lid.
Allows perfusion of the biological sample using a pumping mechanism flowing perfusate in a circuit through the adapter while cooling is provided by cooling blocks around the canister exterior.
Documented Applications
No documented applications found
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